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  • 1
    Electronic Resource
    Electronic Resource
    THE DETERMINATION OF METHANE, CARBON MONOXIDE, AND HYDROGEN BY EXPLOSION IN TECHNICAL GAS ANALYSIS. (1898)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 20 (1898), S. 343-348 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja02067a005
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  • 2
    Electronic Resource
    Electronic Resource
    Metabolism of HDL apolipoprotein A-I and A-II in Type 1 (insulin-dependent) diabetes mellitus (1992)
    Springer
    Diabetologia 35 (1992), S. 347-356 
    Details
    ISSN: 1432-0428
    Keywords: Type 1 (insulin-dependent) diabetes mellitus ; HDL cholesterol ; apolipoprotein A-I ; apolipoprotein A-II ; kinetic analyses ; VLDL triglyceride ; lipolytic enzymes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Concentrations of HDL cholesterol and apolipoprotein A-I are commonly increased in Type 1 (insul-independent) diabetes mellitus but the mechanisms whereby diabetes influences HDL metabolism have not been studied. We investigated the metabolism of HDL apoproteins A-I and II in normolipidaemic Type 1 diabetic men (n=17, HbA1 6.4–11.9%) without microalbuminuria but with a wide range of HDL cholesterol (0.85–2.10 mmol/l) and in nondiabetic men (n=18) matched for body mass index and the range of HDL cholesterol. Input rates and fractional catabolic rates for apolipoproteins A-I and II were determined following injection of 125I-apolipoprotein A-I and 131I-apolipoprotein A-II tracers. Additional multicompartmental analysis was performed using a model to describe the kinetics of HDL particles containing only apolipoprotein A-I (Lp A-I) and apolipoprotein A-I and apolipoprotein A-II (Lp A-I/ A-II). No gross differences from normal subjects were observed in the mean levels of lipids, lipoproteins, apoproteins and the lipolytic enzymes in the diabetic men as a result of the selection process. Furthermore, the relationship between apolipoprotein A kinetics and plasma HDL cholesterol levels appeared to be preserved in the diabetic group. However, some normal interrelationships were disrupted in the diabetic men. Firstly, the rate of apolipoprotein A-II synthesis was 22% lower than in control subjects (p〈0.05). Modelling indicated that this was due to decreased input of Lp A-I/A-II particles whereas the input of Lp A-I particles was similar in the two groups. Secondly, there was no correlation between VLDL triglyceride and HDL cholesterol or VLDL triglyceride and the fractional catabolic rate of apolipoproteins A-I and A-II in diabetic men in contrast to that seen in control subjects. We conclude that there is a disruption in the normal association between VLDL and HDL metabolism in Type 1 diabetic men and postulate that the observed differences may be due to the therapeutic use of exogenous insulin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00401202
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  • 3
    Electronic Resource
    Electronic Resource
    Defective regulation of triglyceride metabolism by insulin in the liver in NIDDM (1997)
    Springer
    Diabetologia 40 (1997), S. 454-462 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Apolipoprotein B ; stable isotopes ; insulin resistance ; non-esterified fatty acids ; cholesterol.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Insulin administration to healthy subjects inhibits the production of very low density lipoprotein (VLDL)1 (Svedbergs flotation (Sf) rate 60–400) without affecting that of VLDL2 (Sf 20–60) subclass. This study was designed to test whether this hormonal action is impaired in non-insulin-dependent diabetes mellitus (NIDDM). We studied six men with NIDDM (age 53 ± 3 years, body mass index 27.0 ± 1.0 kg/m2, plasma triglycerides 1.89 ± 0.22 mmol/l) during an 8.5 h infusion of saline (control) and then in hyperinsulinaemic (serum insulin ∼ 540 pmol/l) conditions during 8.5 h infusions of glucose and insulin to give either hyper- and normoglycaemic conditions. [3-2H]-leucine was used as tracer and kinetic constants derived using a non-steady-state multicompartmental model. Compared to the control study, patients with NIDDM reduced VLDL1 apo B production by only 3 ± 8 % after 8.5 h of hyperinsulinaemia (701 ± 102 vs 672 ± 94 mg/day respectively, NS) in hyperglycaemic conditions and by 9 ± 21 % under normoglycaemic conditions (603 ± 145 mg/day). In contrast, in normal subjects insulin induced a 50 ± 15 % decrement in VLDL1 apo B production (p 〈 0.05). Direct synthesis of VLDL2 apo B in patients with NIDDM was not markedly affected by insulin. We conclude that a contributory factor to hypertriglyceridaemia in NIDDM is the inability of insulin to inhibit acutely the release of VLDL1 from the liver, despite efficient suppression of serum non-esterfied fatty acids. [Diabetologia (1997) 40: 454–462]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250050700
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  • 4
    Electronic Resource
    Electronic Resource
    The pathophysiology of cholesterol metabolism in man (1985)
    Springer
    Journal of molecular medicine 63 (1985), S. 344-351 
    Details
    ISSN: 1432-1440
    Keywords: Lipoprotein ; Receptors ; Drugs ; Hormones
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The concentration of low density lipoprotein in human plasma depends on the balance between its rates of synthesis and catabolism. Although both processes appear to be independently regulated they occur side by side in the liver and may be linked via the activity of the high affinity low density lipoprotein receptor on hepatocyte membranes. Dietary changes such as cholesterol feeding or variation in fat content can promote synthesis of the lipoprotein without changing catabolism while other interventions (e.g. sequestrant resin therapy) have the opposite effect. These different responses may be explained on the basis of compartmentalisation of regulatory sterol pools in the liver cell.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01731653
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  • 5
    Electronic Resource
    Electronic Resource
    Multiple endocrine neoplasia type 1 (MEN1) in two Asian families (1994)
    Springer
    Human genetics 〈Berlin〉 94 (1994), S. 468-472 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Multiple endocrine neoplasia type 1 (MEN1), an autosomal dominant disease characterized by neoplasia of the parathyroid glands, anterior pituitary and endocrine pancreas, is rarely reported in Asian populations. The MEN1 gene, mapped to chromosome 11q13 but yet to be cloned, has been found to be homogeneous in Caucasian populations through linkage analysis. Here, two previously unreported Asian kindreds with MEN1 are described; link-age analysis using microsatellite polymorphic markers in the MEN1 region was carried out. The first kindred, of Mongolian-Chinese origin, is a multigeneration family with over 150 living members, eight of whom are affected to
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00211009
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  • 6
    Electronic Resource
    Electronic Resource
    Twelve years of ground-tilt measurements on the Soufriere of St. Vincent, 1977–1989 (1990)
    Springer
    Bulletin of volcanology 52 (1990), S. 227-241 
    Details
    ISSN: 1432-0819
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract Five ground-tilt stations were established on the flanks of the Soufriere of St. Vincent; two in 1977, two in 1980, and one in 1983. Four of these stations have survived; two consist of lines oriented radially to the volcano, and the other two consist of cross-shaped arrays. Collectively, this network showed that the volcano inflated gradually before the eruption of 1979 and then deflated rapidly during the eruption and for about a year after it had ended. The volcano then reinflated during much of 1981 and inflated only slightly, if at all, during the 7-year period 1982–1989. The measured amount of ground tilt from 1977 to 1989 was relatively small; the maximum recorded change of radial tilt at a station 6.5 km from the summit of the volcano totaled about 20 μrad. Local seismicity correlates well with measured ground deformation: numerous earthquakes accompanied the 1979–1981 deflation/inflation cycle; relatively few earthquakes occurred during the 1982–1989 period of little or no ground deformation. In the hope that the experience we have gained might be of use to others who are considering a program of ground-tilt monitoring on volcanoes elsewhere in the humid tropics, we describe many practical aspects of our program that have evolved over the years. For example: (1) stainless steel bench marks cemented into solid bedrock appear to be stable for at least 12 years, (2) bench marks can be located in concrete-filled drums where bedrock is absent, (3) bench marks should be concealed to protect them from vandalism, (4) care must be exercised where sight lines graze the ground (〈0.5 m), and (5) automatic levels are preferable because of their efficiency of operation, especially with inexperienced personnel.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00334806
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  • 7
    Electronic Resource
    Electronic Resource
    Authors' reply (1994)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 101 (1994), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1994.tb13668.x
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  • 8
    Electronic Resource
    Electronic Resource
    Tamoxifen and the gynaecologist (1993)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 100 (1993), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1993.tb15101.x
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  • 9
    Electronic Resource
    Electronic Resource
    Multicentric carcinoma of the genital tract (1994)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 101 (1994), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1994.tb11954.x
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  • 10
    Electronic Resource
    Electronic Resource
    Wound recurrence by implantation of a borderline ovarian tumour following laparoscopic removal (1994)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 101 (1994), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1994.tb13128.x
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