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  • 1
    ISSN: 1432-1106
    Keywords: Cerebellum ; Pedunculotomy ; Autoradiography ; Retrograde fluorescence ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A left cerebellar pedunculotomy was carried out in neonatal rats of different ages to deprive the left cerebellar hemisphere of its normal climbing fibre input. In control adult animals this is totally crossed and thus arises only from the contralateral (right) inferior olive. After pedunculotomy, only the left inferior olive was intact, the right being degenerated. The remaining olivocerebellar pathway was investigated using anterograde autoradiographic or retrograde fluorescent double-labelling techniques. The anterograde autoradiographic technique showed that, in these animals, the remaining left inferior olive had an aberrant climbing fibre projection which travelled via the intact right inferior cerebellar peduncle to the denervated left hemicerebellum. If the pedunculotomy was carried out at 3 days of age (P3), this aberrant projection closely mirrored the normal pathway to the opposite hemisphere; pedunculotomy at P7 produced a different pattern of projection; while if the operation was done at P10 there was no new projection. True blue (TB) and diamidino yellow (DY) were injected into the denervated (left) and normal (right) cerebellar hemispheres respectively. Retrograde transport of these tracers confirmed both the aberrant ipsilateral projection and the normal crossed projection from neurons in the remaining inferior olive. Most of the ipsilaterally projecting neurons were in the medial accessory olive. As none of them were double-labelled, it was concluded that the new projection is not a collateral of normally projecting olivary neurons, but arises from a separate population of cells. The significance of these findings in relation to earlier work on this system is discussed.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Experimental brain research 61 (1986), S. 355-363 
    ISSN: 1432-1106
    Keywords: Cerebellum ; Pedunculotomy ; Auto-radiography ; Climbing fibres
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Using autoradiographic techniques the olivocerebellar pathway was investigated in neonatal rats which had undergone a left cerebellar pedunculotomy on postnatal day 7 (p7). Tritiated (3H) leucine was injected into the right inferior olive at the same time as the pedunculotomy and the animals were allowed to survive for two or four days. Autoradiographs were then made of the brainstem and the cerebellum. Only those animals which had had a total left cerebellar pedunculotomy and in which the 3H-leucine did not spill into the left inferior olive were included in the experiment. The results showed the presence of climbing fibres in the cerebellar hemisphere ipsilateral to the injection site, arranged in sagittal bands and topographically organised. The only route for those fibres to enter the cerebellum is through the inferior cerebellar peduncle ipsilateral to the injected olive which is a pathway not present in the adult animal. The possible explanations for these results are discussed.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 42 (1986), S. 1218-1220 
    ISSN: 1420-9071
    Keywords: Cerebellum ; pedunculotomy ; blood supply ; development
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary After cerebellar pedunculotomy the density of the blood vessel network in the cerebellar cortex was not different from that in the control animals. But the pattern of the blood vessels was different, being less organized in the operated animals.
    Type of Medium: Electronic Resource
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