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  • 1
    Electronic Resource
    Electronic Resource
    Molecular genetics of the complement C3 convertases in lower vertebrates (1998)
    Oxford, UK : Blackwell Publishing Ltd
    Immunological reviews 166 (1998), S. 0 
    Details
    ISSN: 1600-065X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary: Evolution of the two gene families of the complement system involved in the formation of the C3 convertases, B/C2 andC3/C4/C5, was studied at the cDNA level in lower vertebrates. Cyclostomes, the most primitive extant vertebrates, seem to possess only one member each of these families, indicating chat gene duplication between B and C2 or among C3, C4 and C5 occurred in the lineage of jawed vertebrates. Typical C3 and C4 cDNAs were identified in both amphibian (Xenopus) and teleost (medaka fish), locating the C3 /C4 gene duplication before the divergence of ray funned fish and lobe-finned Fish, On the other hand, typical B cDNA was identified in Xenopus, whereas teleost counterparts from three species all showed intermediate character between B and C2, suggesting the possibility that the B/C2 gene duplication occurred in die tetrapod lineage. Genetic linkage between these two family genes within the MHC was observed in Xenopus but not in medaka fish.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-065X.1998.tb01252.x
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  • 2
    Electronic Resource
    Electronic Resource
    Mutations in the gene encoding B, a novel transporter protein, reduce melanin content in medaka (2001)
    [s.l.] : Nature Publishing Group
    Nature genetics 28 (2001), S. 381-385 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Pigmentation of the skin is of great social, clinical and cosmetic significance. Several genes that, when mutated, give rise to altered coat color in mice have been identified; their analysis has provided some insight into melanogenesis and human pigmentation diseases. Such analyses do not, ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/ng584
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  • 3
    Electronic Resource
    Electronic Resource
    Number of major histocompatibility loci in inbred strains of the fishOryzias latipes (1989)
    Springer
    Immunogenetics 30 (1989), S. 226-228 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02421212
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  • 4
    Electronic Resource
    Electronic Resource
    Molecular cloning and linkage analysis of the Japanese medaka fish complement Bf/C2 gene (1996)
    Springer
    Immunogenetics 44 (1996), S. 459-467 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract  Evolutionary studies of complement factor B (Bf) and C2 in lower vertebrates have revealed the presence of the Bf/C2 common ancestor-like molecule in lamprey (cyclostome) and the Bf molecule encoded by the duplicated genes closely linked to the major histocompatibility complex (MHC) in Xenopus (amphibian). To further define when Bf/C2 gene duplication occurred and when linkage between the Bf/C2 gene and the MHC was established, we amplified the Bf/C2 sequences in teleost, the Japanese medaka (Oryzias latipes), by reverse transcription – polymerase chain reaction with primers corresponding to the common amino acid sequences shared by mammalian Bf and C2. Only a single molecular species has been amplified, and the corresponding cDNA clones were isolated from the liver cDNA library. The longest insert contained 2384 nucleotides with an open reading frame of 754 residues. The deduced amino acid sequence showed 33.6% and 34.1% overall identity with the human Bf and C2 sequences, respectively, hence this clone was named medaka Bf/C2. The single-copy medaka Bf/C2 gene had exactly the same exon-intron organization as the mammalian Bf and C2 genes, and spanned about 8 kilobases. The Bf/C2 locus was mapped to the close proximity (2.9 cM) of the superoxide dismutase locus on the linkage group XX by the use of a restriction site polymorphism between two inbred strains of the medaka.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002510050153
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  • 5
    Electronic Resource
    Electronic Resource
    Genetic linkage between the LMP2 and LMP7 genes in the medaka fish, a teleost (1997)
    Springer
    Immunogenetics 46 (1997), S. 431-433 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002510050298
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  • 6
    Electronic Resource
    Electronic Resource
    Linkage relationships of gene loci in the medaka,Oryzias latipes (Pisces: Oryziatidae), determined by backcrosses and gynogenesis (1989)
    Springer
    Biochemical genetics 27 (1989), S. 183-198 
    Details
    ISSN: 1573-4927
    Keywords: backcross ; gene-centromere mapping ; diploid gynogenesis ; interference ; Oryzias latipes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Linkage relationships of 11 enzyme loci and 2 visible mutant loci were investigated in the Medaka,Oryzias latipes, using backcrosses and gynogenesis. Results of four crosses for three loci were not in agreement with the Mendelian expectation of a 1 homozygote:1 heterozygote segregation ratio. Some locus pairs showed a significant excess of parental types at the 5% confidence limit. At the 1% confidence limit, however, results of all locus pairs analyzed showed nonsignificance. The results of sex-linked locus tests showed that no loci were sex linked at the 1% confidence limit. Under complete interference conditions, gene-centromere distances (cM) were as follows:Me, 2.6;Adh, 10;Sod, 17;Sdh, 18;Pgm, 31;Ck-A, 31;Gpdh, 32;Pgd, 45;Amy, 47; andLdh-A, 50. High heterozygous fractions observed for Pgd, Amy, and Ldh-A suggest that exactly one crossover happened between these genes and their centromeres and that strong interference exists in chromosomes carrying these loci.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00552991
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  • 7
    Electronic Resource
    Electronic Resource
    Linkage relationships of gene loci in the medaka,Oryzias latipes (Pisces: Oryziatidae), determined by backcrosses and gynogenesis (1989)
    Springer
    Biochemical genetics 27 (1989), S. 183-198 
    Details
    ISSN: 1573-4927
    Keywords: backcross ; gene-centromere mapping ; diploid gynogenesis ; interference ; Oryzias latipes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Linkage relationships of 11 enzyme loci and 2 visible mutant loci were investigated in the Medaka,Oryzias latipes, using backcrosses and gynogenesis. Results of four crosses for three loci were not in agreement with the Mendelian expectation of a 1 homozygote:1 heterozygote segregation ratio. Some locus pairs showed a significant excess of parental types at the 5% confidence limit. At the 1% confidence limit, however, results of all locus pairs analyzed showed nonsignificance. The results of sex-linked locus tests showed that no loci were sex linked at the 1% confidence limit. Under complete interference conditions, gene-centromere distances (cM) were as follows:Me, 2.6;Adh, 10;Sod, 17;Sdh, 18;Pgm, 31;Ck-A, 31;Gpdh, 32;Pgd, 45;Amy, 47; andLdh-A, 50. High heterozygous fractions observed for Pgd, Amy, and Ldh-A suggest that exactly one crossover happened between these genes and their centromeres and that strong interference exists in chromosomes carrying these loci.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02401800
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  • 8
    Electronic Resource
    Electronic Resource
    Comparative study of embryonic thermoresistance of two inbred strains of the medaka (Oryzias latipes) (1991)
    Springer
    Journal of comparative physiology 160 (1991), S. 621-625 
    Details
    ISSN: 1432-136X
    Keywords: Thermoresistance ; Inbred strains ; Embryos ; Maternal factor(s) ; Oryzias latipes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary By using inbred strains (HO4C and HB32C) of the medaka,Oryzias latipes, the involvement of genetic factor(s) in the determination of thermoresistance of fish was investigated. The thermoresistance of embryos of the medaka was quantitated by the fraction of the embryos surviving 1 day after heat treatment. At early stages of development (st. 13 and st. 20–21), the HO4C strain was more resistant than the HB32C strain. At st. 20–21, the HO4C strain was more resistant than the HB32C strain at all temperatures used (42, 43, and 44°C). At later stages of development (st. 27 and st. 32), however, the HB32C strain was more resistant than the HO4C strain. The results of genetic cross experiments raised the following possibilities; the thermoresistance of embryos at early developmental stages can be lowered by some factor(s) inherited in the HO4C strain and/or increased by those in the HB32C strain. By contrast, the sensitivity of embryos at later stages of development was not affected by factor(s) of their parents, but by their own genetic constitution.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00571259
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