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  • 1
    Electronic Resource
    Electronic Resource
    cDNa subtraction library construction using a magnet-assisted subtraction technique (MAST)
    Amsterdam : Elsevier
    Trends in Genetics 9 (1993), S. 70-71 
    Details
    ISSN: 0168-9525
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0168-9525(93)90216-5
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    ISO-SWS Spectral Characterization of Stars (1997)
    Springer
    Astrophysics and space science 255 (1997), S. 251-253 
    Details
    ISSN: 1572-946X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1001158901391
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Loss of heterozygosity on chromosome 11p13 in primary bladder carcinoma (1993)
    Springer
    Human genetics 〈Berlin〉 91 (1993), S. 455-458 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Although the occurrence of bladder cancer is common, the molecular events underlying the pathogenesis of this cancer remain ill-defined. A loss of heterozygosity (LOH) at specific chromosomal loci may predispose individuals to the development of bladder cancer but this has not been examined in detail. Furthermore, the role that deletion or inactivation of putative tumour suppressor genes might play in the genesis of bladder cancer has not been established. In this study, allelic deletion analysis on the short arm of chromosome 17 of patients with primary bladder tumours failed to show deletion at 17p13 (0/7), a region known to contain the p53 tumour suppressor gene. Chromosome 11p15 showed allelic deletion at the IGF2 locus (2/7: 29%) and the PTH locus (1/11: 9%). However, no deletion was observed at the CALCA locus (0/6). LOH at 11p13, a region containing the Wilm's tumour suppressor gene (WT1), was also studied. Analysis of LOH at 11p13 showed deletion at the CAT locus (13/18: 72%), the ΔJ/D11S414 locus (5/15: 33%), the WT1 locus (7/14: 50%) and the FSHB locus (6/16: 38%). The significance of these findings is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00217771
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Eos — An Evolutionary and Ecosystem Research Platform (2000)
    Springer
    BT technology journal 18 (2000), S. 24-31 
    Details
    ISSN: 1573-1995
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology
    Notes: Abstract The Eos platform supports research and rapid implementation of evolutionary algorithms, ecosystem simulations and hybrid models. It also supports fast prototyping of industrial applications using these technologies. A large and rapidly growing library of evolutionary algorithm types and options is provided which together with a flexible configuration system allows a 'plug-and-play' construction of novel algorithms. Support for ecosystem models includes classes for multiple types of physical space (n-dimensional discrete or continuous Cartesian space, graph space), complex interactions between entities, and movement of individuals between populations. The flexibility of the Eos platform is expected to provide a powerful environment for developing new algorithms and architectures. Eos is implemented in Java™ for portability and to allow easy extension of the core functionality. It supports transparent distribution of evolutionary and ecosystem implementations across multi-processor computer clusters. This paper describes the architecture and functionality of the Eos platform and illustrates its use by way of a number of example applications.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1026798423593
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  • 5
    Electronic Resource
    Electronic Resource
    The Use of Neutral Genotype-Phenotype Mappings for Improved Evolutionary Search (2000)
    Springer
    BT technology journal 18 (2000), S. 103-111 
    Details
    ISSN: 1573-1995
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology
    Notes: Abstract In natural systems, the organism or phenotype is the result of a complex developmental process that is played out as the genetic information is interpreted. This is in stark contrast to many artificial evolutionary systems in which the phenotype is represented directly in the genetic information and there is no such development. As well as overcoming the obvious practical impossibility of directly specifying an organism in the genotype, the developmental process may yield other desirable properties. One such property is neutrality in which many genotypes develop into the same phenotype. This paper examines the effect of neutral genotype-phenotype mappings on artificial evolutionary systems through examination of an abstract redundant mapping based on a random Boolean network (RBN). It then goes on to examine the genotype-phenotype mapping within a planning tool that evolves instructions for growing telecommunications networks. It is demonstrated how the right kind of redundancy has the potential of significantly aiding the evolvability of a system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1026714927227
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  • 6
    Electronic Resource
    Electronic Resource
    Coupling Developmental Rules and Evolution to Aid in Planning Network Growth (2000)
    Springer
    BT technology journal 18 (2000), S. 95-102 
    Details
    ISSN: 1573-1995
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology
    Notes: Abstract In order to meet the increasing demand for capacity on BT's telecommunications networks, they must be grown. Planning such growth in order to cost effectively meet the projected demand is thus an important concern. This paper describes a tool that was developed to aid in such a task. The system employs a simulation of both the network and the demand that must be satisfied. A set of planning rules are defined which are triggered by conditions in the simulated network and result in the addition or reconfiguration of hardware in an attempt to better accommodate the simulated demand. A genetic algorithm is employed to evolve the parameters of these rules with the overall effect of optimising the resulting networks against constraints of cost and quality of service. In this way, much like the real world, evolution is a modifier of the dynamics of a developmental process. Application of the tool is demonstrated on a specific instance of network growth — the dial-up IP access network that requires rapid expansion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1026762810389
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Single-cell protein production by photosynthetic bacteria cultivation in agricultural by-products (1975)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 17 (1975), S. 1561-1570 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The growth of the nonsulfur photosynthetic bacterium Rhodopseudomonas gelatinosa was investigated as a possible way to produce single-cell protein from agricultural by-products. Of the various raw materials examined as potential feedstocks, wheat bran infusion was selected as the substrate for mass culture and continuous cultivation studies. Harvested photosynthetic cells contained approximately 65.0% crude protein and 5.1% nucleic acid (RNA). The amino acid content of harvested photosynthetic proteins was comparable with conventional proteins of plant and animal origin.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260171102
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    Paper (German National Licenses)
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