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  • 1
    Electronic Resource
    Electronic Resource
    Effect of zinc administration on thyrotropin releasing hormone-stimulated prolactinemia in healthy men (1999)
    Springer
    BioMetals 12 (1999), S. 347-352 
    Details
    ISSN: 1572-8773
    Keywords: zinc tolerance test ; thyrotropin tolerance test ; prolactin secretion ; healthy men
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Previous in vitro studies have demonstrated zinc (Zn++) inhibition of basal and of potassium (K+) or thyrotropin-releasing hormone (TRH)-stimulated prolactin (PRL) secretion, in a selective, reversible, and dose-dependent manner. Thus, Zn++ may regulate physiologically pituitary PRL secretion. Furthermore, studies with patients with uremia, cirrhosis or prolactinoma, have shown the coexistence of hypozincemia and hyperprolactinemia and zinc supplementation did not correct hyperprolactinemia in these patients. In normal individuals Zn++ administration produced controversial results on PRL secretion. Here, we investigated whether zinc administration affects TRH-stimulated PRL in healthy men. We found that Zn++ administration does not change the TRH-stimulated PRL. Therefore, in normal conditions, Zn++ does not inhibit TRH-stimulated prolactinemia. In addition, we found that acute increases of blood PRL and TRH do not alter blood Zn++ levels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1009225904221
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Lack of acute zinc effects in glucose metabolism in healthy and insulin-dependent diabetes mellitus patients (1999)
    Springer
    BioMetals 12 (1999), S. 161-166 
    Details
    ISSN: 1572-8773
    Keywords: zinc ; glucose ; C-peptide ; glucagon ; cortisol ; diabetes mellitus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Acute or chronic zinc administration may cause hyperglycemia in experimental animals. These findings are attributed to permissive actions of glucocorticoids and glucagon upon hepatic gluconeogenesis and glycogenolysis. The effect of Zn++ on plasma glucose, C-peptide, glucagon, and cortisol was investigated in healthy and insulin-dependent diabetes mellitus (IDDM) patients. Ten normal individuals (5 of each sex, aged 24.10 ± 1.96) and 10 IDDM (5 of each sex, aged 25.20 ± 8.10) were tested at 7:00 AM after 12-h fast. Twenty-five mg of Zn++ were administered intravenously during 1 min, and blood samples were collected from the contralateral arm at 0, 3, 30, 60, 90 and 120 min after Zn++ injection. The plasma levels of glucose, C-peptide, and glucagon remained constant throughout the experimental period in both groups studied. Plasma cortisol levels decreased significantly, which is consistent with our previous findings. These results suggest that, in contrast to experimental animals, acute Zn++ administration, despite decreasing cortisol levels, does not change carbohydrate metabolism in human beings.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1009254424394
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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