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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc.
    Journal of cutaneous pathology 32 (2005), S. 0 
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A 31 year-old female presented with fever, arthralgias and myalgia ten days after returning from Zimbabwe. On physical exam she had scattered small, pink papules over the lower abdomen and two hemorrhagic pustules with central necrosis (eschars) on her left leg and left buttock. There was inquinal lymphadenopathy with no splenomegaly or hepatomegaly. A punch biopsy was performed which showed necrotizing vasculitis with ulceration of overlying epidermis and papillary dermis. Immunohistochemical studies performed at the Center for Disease Control and Prevention were positive for spotted group Rickettsiae. Treatment with doxycycline 200 mg/d for two weeks resulted in complete recovery. The clinical and histopathologic findings were consistent with Tick Bite Fever caused by Rickettsia africae.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Experimental dermatology 1 (1992), S. 0 
    ISSN: 1600-0625
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract Reactive oxygen species (ROS) produced by phagocytic cells induce oxidative stress during chronic inflammation, ROS play a role in the pathogenesis of a broad range of diseases including autoimmune, cardiac and neoplastic abnormalities. We found that sera of patients with a variety of inflammatory dermatoses contain elevated levels of antibodies (Ab) binding to an oxidized DNA base derivative, 5-hydroxyme-thyl-2′deoxyuridine (HMdU) coupled to bovine serum albumin, as determined by the enzyme-linked immunosorbent assay. Patients with immune complex diseases and a history of neoplasm elaborated the highest titers of anti-HMdU Ab. Titers from sera of psoriatic subjects were lower than from the aforementioned groups but were still significantly elevated (p〈0. 001) above those of healthy controls. Treatment of inflammatory dermatoses with systemic antiinflammatory and cytotoxic drugs significantly lowered the titers [p〈0. 005 (immune complex) or p〈0. 001 (psoriasis and neoplastic) diseases], suggesting that this assay may be of value in monitoring the response to therapy in these diseases.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-069X
    Keywords: Systemic cytotoxic therapy ; Systemic anti-inflammatory therapy ; UVB phototherapy ; Anti-HMdU antibodies ; Psoriasis ; Immune complex disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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