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  • 1
    Electronic Resource
    Electronic Resource
    The effect of collagenase-inhibitor complexes on collagenolytic activity of normal and inflamed gingival tissue (1973)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 2 (1973), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract. The effect of serum inhibitors on determinations of collagenolytic activity in culture fluids of healthy (G.I.=0) and mildly inflamed (G.I.=1) gingival tissue was studied. Gingival biopsies obtained at the beginning of the experimental gingivitis period (G.I.=0) and after approximately three weeks of no oral hygiene (G.I.=1) were subjected to tissue culture procedures previously utilized for the determination of collagenolytic activity. Inhibition of collagenase activity was evaluated by denaturing scrum inhibitors retained in culture fluid with sodium thiocyanate or by adding culture fluid from normal and inflamed tissues to a partially purified collagenase preparation.A decrease in collagenolytic activity was consistently demonstrable in untreated culture fluids of gingival tissue manifesting G.I.=1 as compared lo those exhibiting G.I.=0. When enzyme containing culture fluids were treated with NaSCN. however, no essential difference was detected. While culture fluids from healthy gingiva showed no inhibition of partially purified collagenase, culture fluids from tissues manifesting mild inflammation inhibited enzyme activity by approximately 60 %.A number of cell types associated with the periodontium have the ability to produce a specific collagenase. The results of this investigation suggest, however, that in vitro determinations of collagenolytic activity in culture fluids of normal and inflamed tissues may be influenced by specific scrum inhibitors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0714.1973.tb01671.x
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  • 2
    Electronic Resource
    Electronic Resource
    Polymorphonuclear leukocyte collagenase: Localization in granules subjected to zonal centrifugation (1972)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 1 (1972), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract. Polymorphonuclear leukocytes were obtained from rabbit peritoneal exudates. Granule preparations from these cells were subjected to zonal fractionation through a discontinuous sucrose gradient. Azurophilic and specific granules were enzymatically characterized by peroxidase and alkaline phosphatase, respectively. Collagenase was consistently associated with the alkaline phosphatase-containing specific granules.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0714.1972.tb01908.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Hypothalamic monoaminergic mechanisms of aspirin-induced analgesia in monkeys (1985)
    Springer
    Journal of neural transmission 62 (1985), S. 285-293 
    Details
    ISSN: 1435-1463
    Keywords: Aspirin ; analgesia ; monoamines ; hypothalamus ; jaw-opening reflex
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Microinjection of sodium acetylsalicylate (aspirin, 0.2–0.6 mg) into the preoptic anterior hypothalamic area, but not the dorsal raphe region or the periaqueductal central gray matter, produced a dose-related analgesia in conscious monkeys. The analgesia induced by intrahypothalamic administration of aspirin was antagonized by pretreatment of monkeys with either a serotoninergic receptor blocker (cyproheptadine) or two catecholaminergic receptor blockers (haloperidol and yohimbine). These suggest the existence of a monoaminergic pain-inhibitory mechanism in the preoptic anterior hypothalamic area activated by aspirin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01252242
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    Paper (German National Licenses)
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