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  • 1
    Electronic Resource
    Electronic Resource
    Nanocrystalline CNT-TiO〈sub〉2〈/sub〉 Composites Produced by an Acid Catalyzed Sol-Gel Method (2008)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 587-588 (June 2008), p. 849-853 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Carbon nanotube-TiO2 composites and pure TiO2 are prepared by a modified sol-gelmethod. The nanoscaled materials obtained are extensively characterized by spectroscopic,microscopic and calorimetric techniques. Their photoactivity is tested in the degradation of phenolunder visible illumination. A correlation between the CNT content and the changes in the UV–visabsorption properties was found. The effect induced by CNT on the composite catalysts is explainedin terms of an interphase interaction between CNT and TiO2 in the composite catalysts
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/19/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.587-588.849.pdf
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  • 2
    Electronic Resource
    Electronic Resource
    Expression of TGF-α and EGFR in Breast Cancer and its Relation to Angiogenesis (2000)
    Boston, MA, USA : Blackwell Science Inc
    The @breast journal 6 (2000), S. 0 
    Details
    ISSN: 1524-4741
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Immunohistochemical analysis of the expression of transforming growth factor α (TGF-α) and its receptor, epidermal growth factor receptor (EGFR), was performed in a series of 86 invasive carcinomas of the breast. TGF-α immunostaining was observed in the majority of the cases (72.1%), both in epithelial cells and in adjacent stromal cells. EGFR was also present in tumors (34.2%) and in the endothelial cells (46.1% of the cases) near the tumors. A significant association was observed between TGF-α expression and angiogenesis evaluated by immunohistochemistry using an antibody against factor VIII-related antigen. No association was observed between TGF-α expression and other clinicopathologic features. In contrast, EGFR expression in the tumor was associated with features of poor prognosis, such as tumor size, histologic grade, lymph node status, estrogen receptor content, p53 expression, sialyl-Tn expression, and age. The presence of EGFR in endothelial cells was correlated to young patient age. We also observed an association of EGFR in endothelial cells and angiogenesis in tumors with a size of less than 2 cm. Inversely, in larger tumors, angiogenesis was only associated with tumor TGF-α expression. These results indicate that endothelial EGFR may play a role in the early steps of breast cancer angiogenesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1524-4741.2000.98046.x
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  • 3
    Electronic Resource
    Electronic Resource
    Indole-based analogs of melatonin: in vitro antioxidant and cytoprotective activities (2004)
    Oxford, UK : Munksgaard International Publishers
    Journal of pineal research 36 (2004), S. 0 
    Details
    ISSN: 1600-079X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract:  The known neuroprotective actions of melatonin could be due to its antioxidant or radical scavenging activity, or they could be due to specific interactions of the indole with its receptors. A study of structure–activity relationships may provide useful information when a validated macromolecular target has not been (or is not) identified. A set of indole derivatives, with changes in the 5-methoxy and acylamino groups, the side chain position and the lipophilic/hydrophilic balance, were selected and tested for their in vitro antioxidant potency in the ABTS (2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonic acid disodium salt) and thiobarbituric acid reactive substances (TBARS) assays and for their cytoprotective activity against kainate excitotoxicity on cerebellar cell cultures. No quantitative model was able to relate the potencies obtained in the two antioxidant assays, probably because they are related to different physico-chemical properties. However, the lipophilicity of the compounds and the antioxidant potency in the TBARS assay were linearly correlated. This may be due to improved access to the lipidic substrate, where the antioxidant action occurs. In the cytoprotection assay, most compounds showed potencies comparable with or lower than melatonin. An exception was N-[2-(5-methoxy-1H-indol-2-yl)ethyl]acetamide (12), yielding, at 50 μm, percentages of cell vitality higher than 75%, while melatonin EC50 was 333 μm. No correlation was observed between cytoprotective and antioxidant potencies, nor with MT1 or MT2 receptor affinity. Compound 12 is a low-affinity antagonist at melatonin membrane receptors, and one of the most potent compounds in the antioxidant assays; its cytoprotective potency and the absence of agonist activity at melatonin membrane receptors make it a valid candidate for further investigations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1600-079X.2003.00102.x
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  • 4
    Electronic Resource
    Electronic Resource
    Facilitation of the vasorelaxant action of calcium antagonists by basal nitric oxide in depolarized artery (1996)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 354 (1996), S. 505-512 
    Details
    ISSN: 1432-1912
    Keywords: Calcium antagonists ; Isradipine ; Nisoldipine ; Lacidipine ; Verapamil ; Diltiazem ; Nitric oxide ; Isolated artery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We investigated the effect of NO/cyclic GMP pathway on the action of calcium antagonists (isradipine, nisoldipine, lacidipine, verapamil, diltiazem) in rat aorta exposed to 100 mM KCl. For this purpose constitutive NO synthase was blocked by using 100 μM Nω-nitro-l-arginine (l-NNA). The steady-state contractile response evoked by 100 mM KCl was enhanced when the basal NO release had been blocked. The combined effects of basal NO release and calcium antagonists resulted in an inhibition greater than additive. Concentrations of calcium antagonists producing 50% inhibition of contraction were about 3-fold lower in the presence of the basal NO release than in its absence (P 〈 0.01). 45Ca2− influx stimulated by 100 mM KCl was not affected by the basal NO release, but was inhibited by isradipine and verapamil regardless of NO blockade. Thus, the facilitation of the action of calcium antagonists by NO/cyclic GMP pathway seemed not to be accompanied by a modification of their action on L-type calcium channels. To confirm this, we measured the contractile tension and the calcium signal in fura-2 loaded rings, pretreated with either verapamil or verapamil plus 8-bromo cyclic GMP (BrcGMP), and further exposed to increasing concentrations of extracellular Ca2− ([Ca2+]o) in 100 mM KCl solution. The increase in cytosolic Ca2+ ([Ca2+]cyt) evoked by increasing ([Ca2+]o) in rings pretreated with verapamil alone was not different from rings pretreated with verapamil plus BrcGMP. In contrast, the [Ca2+]o-contraction curve was significantly shifted to the right in rings pretreated with verapamil plus BrcGMP. These results show that the NO/cyclic GMP pathway facilitates the inhibitory effect of calcium antagonists on 100 mM KCl-evoked contraction. This phenomenon is not related to a modification of calcium channel blockade, but could result from the reduction of the sensitivity of contractile machinery to Ca2+ by cyclic GMP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00168443
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