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  • 1
    Electronic Resource
    Electronic Resource
    Update on Lower Extremity Endovascular Interventions (1998)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of interventional cardiology 11 (1998), S. 0 
    Details
    ISSN: 1540-8183
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In the past decade there have been major strides in the development of devices and techniques for nonsurgical lower extremity revascularization. These advances have broadened indications for endovascular therapies and expanded the treatment options for patients with peripheral vascular disease. A variety of new laser-etched steel and nitinol stent designs now complement balloon angioplasty. In the iliac segment, stenting has replaced balloon angioplasty as the first-line therapy for treatment of symptomatic occlusive disease. Stenting results in superior acute procedural success and long-term clinical efficacy compared to balloon angioplasty and is a “less invasive” alternative to surgical reconstruction. Endoluminal stent grafts offer promise in the treatment of high-risk patients with abdominal aortic aneurysms. New strategies are being developed to address the diverse nature of the superficial femoral artery (SFA) and infrapopliteal disease where balloon angioplasty, stenting, and stent graft strategies have proven unsatisfactory for treatment of diffuse disease and long occlusions. The next millennium will see the use of “therapeutic angiogenesis,” the intravascular and intramuscular administration of DNA fragments or proteins, to stimulate new vessel growth in patients not amenable to conventional surgical or endovascular therapies. Brachytherapy, the intravascular delivery of a retrievable ionizing radiation source, represents an exciting development that offers the potential of reducing restenosis in the SFA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1540-8183.1998.tb00192.x
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  • 2
    Electronic Resource
    Electronic Resource
    Development of Ovine Follicle-Stimulating Hormone (FSH) and Its Antiidiotypic Antibodies as Vaccines for Male Contraception (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 513 (1987), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1987.tb25093.x
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  • 3
    Electronic Resource
    Electronic Resource
    Interaction of Osteopontin with Fibronectin and Other Extracellular Matrix Molecules (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 760 (1995), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1995.tb44631.x
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  • 4
    Electronic Resource
    Electronic Resource
    Dual reciprocity boundary element analysis of transient advection-diffusion (2003)
    Bradford : Emerald
    International journal of numerical methods for heat & fluid flow 13 (2003), S. 633-646 
    Details
    ISSN: 0961-5539
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: This paper presents an application of the dual reciprocity boundary element method (DRBEM) to transient advection-diffusion problems. Radial basis functions and augmented thin plate splines (TPS) have been used as coordinate functions in DRBEM approximation in addition to the ones previously used in the literature. Linear multistep methods have been used for time integration of differential algebraic boundary element system. Numerical results are presented for the standard test problem of advection-diffusion of a sharp front. Use of TPS yields the most accurate results. Further, considerable damping is seen in the results with one step backward difference method, whereas higher order methods produce perceptible numerical dispersion for advection-dominated problems.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1108/09615530310482481
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  • 5
    Electronic Resource
    Electronic Resource
    The cortical topography of human swallowing musculature in health and disease (1996)
    [s.l.] : Nature Publishing Group
    Nature medicine 2 (1996), S. 1217-1224 
    Details
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Because no detailed information exists regarding the topographic representation of swallowing musculature on the human cerebral cortex in health or disease, we used transcranial magnetic stimulation to study the cortical topography of human oral, pharyngeal and esophageal musculature in 20 healthy ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nm1196-1217
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  • 6
    Electronic Resource
    Electronic Resource
    An Experimental Evidence Of Non-Ducted Propagation During Daytime From The Esd Whistler Observations At Low Latitude Ground Station Jammu (1999)
    Springer
    Earth, moon and planets 84 (1999), S. 151-162 
    Details
    ISSN: 1573-0794
    Keywords: Dispersion ; magnetosphere ; whistlers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract The propagationmechanism of low latitude daytime whistlers is investigated on the basis of ground measurements made continuously during daytime in North India at Jammu (geomag. lat. 22°26°N;L = 1.17). On February 14, 1998 extremely small dispersion (ESD) whistlers with dispersion varying from 5–10 sec1/2 in surprisingly large numbers were recorded at Jammu during daytime in the late afternoon. The results of a study of the characteristics of ESD whistlers are presented and the discussion indicates that ESD whistlers recorded are the VLF waves radiated from the return stroke of the lightning discharge launched at the ionosphere with different initial wave normal angles, propagated upwards under eitherquasi-longitudinal conditions or pro-longitudinal whistler mode, turned around at different heights due to quasi-transverse propagation and received at Jammu with the dispersion of the order of 5–10 sec1/2. The validity of this suggestion has been tested by performing actualray-tracing computations in thepresence of equatorial anomaly model.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018959818988
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  • 7
    Electronic Resource
    Electronic Resource
    Changes in Gene Expression during the Transition from Compensated Hypertrophy to Heart Failure (1999)
    Springer
    Heart failure reviews 4 (1999), S. 361-378 
    Details
    ISSN: 1573-7322
    Keywords: gene expression ; heart failure ; hypertrophy ; cell signaling ; E-C coupling ; extracellular matrix ; neurohormones ; growth factors ; cytokines ; apoptosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract With the advancement in molecular techniques for characterizing genes and the use of animal models as tools to study heart failure, considerable progress has been made in improving our understanding of the regulation and function of genes associated with heart failure. Studies now indicate that autocrine/paracrine factors including neurohormones such as norepinephrine, angiotensin II, proinflammatory cytokines and peptide growth factors produced locally in the heart may affect myocyte growth and function through intricate signaling mechanisms. While changes in gene expression for the proteins involved in cell signaling may lead to myocyte hypertrophy and/or apoptosis, alteration in calcium homeostasis, excitation-contraction coupling and the extracellular matrix also contribute to systolic and diastolic dysfunction leading to heart failure. Thus, heart failure is a complex process, which involves changes in expression of multiple genes. With the advent of new techniques involving microarray and gene chip technology, it is now possible to define and/or identify sets of genes involved in heart failure. The purpose of this review is to provide an overview of molecular signals, intracellular signaling mechanisms and the changes in gene expression associated with the transition from compensated hypertrophy to failure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1009855720081
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  • 8
    Electronic Resource
    Electronic Resource
    Inhibition of protein phosphatase 1 induces apoptosis in neonatal rat cardiac myocytes: role of adrenergic receptor stimulation (2000)
    Springer
    Basic research in cardiology 95 (2000), S. 389-396 
    Details
    ISSN: 1435-1803
    Keywords: Key words Apoptosis – okadaic acid – myocytes – phosphorylation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The mechanisms that regulate cardiac myocyte apoptosis are not well understood. To study the role of protein phosphatase 1 (PP1) and 2A (PP2A) in apoptosis, we exposed cultured neonatal rat cardiac myocytes to the phosphatase inhibitor okadaic acid (OA). Exposure (18 h) to 100 nM OA (a concentration which inhibits both PP1 and PP2A) decreased the number of adherent cells, caused genomic DNA fragmentation, and increased the percentage of apoptotic cells. These effects did not occur at a lower concentration of OA (1 nM) which is relatively specific for PP2A. Stimulation of α1- or β-adrenergic receptors with norepinephrine (NE) in the presence of propranolol or prazosin partially blocked OA-induced apoptosis as measured by flow cytometry. Likewise, stimulation of adenylyl cyclase with forskolin reduced OA-induced apoptosis. Conversely, inhibition of protein kinase A with H89 or protein kinase C with chelerethrine potentiated OA-induced apoptosis. OA increased caspase-3 activity, and this effect was reduced by NE. Thus, inhibition of PP1 stimulates apoptosis in NRVM and stimulation of adrenergic receptors protects against OA-induced apoptosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003950070038
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  • 9
    Electronic Resource
    Electronic Resource
    Three and four step least squares finite element schemes in the time domain (1996)
    Chichester : Wiley-Blackwell
    Communications in Numerical Methods in Engineering 12 (1996), S. 425-431 
    Details
    ISSN: 1069-8299
    Keywords: time integration ; finite element method ; least squares formulation ; multistep methods ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: The paper presents a formulation and analysis of three and four step least squares algorithms for first order IVPs. The three step algorithm is derived using cubic Lagrangian interpolation, and is found to be third order accurate but only conditionally stable. Fourth order Lagrangian interpolation is used to obtain a four step least squares scheme which is A0-stable but inconsistent.
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
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    Paper (German National Licenses)
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