Library

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 54 (1976), S. 671-676 
    ISSN: 1432-1440
    Keywords: Strophanthin ; Spirolactone ; Digitalis tolerance ; Myocardial potassium depletion ; Na+, K+ membrane ATPase ; Spirolactone ; Strophanthin ; Digitalistoleranz ; Myokardialer Kaliumverlust ; Na+-K+-MembranATPase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Zur Prüfung der Frage, ob eine Verbesserung der Digitalistoleranz unter Spirolactone durch eine gegensinnige Beeinflussung der myokardialen Kaliumbilanz mitbedingt wird, erhitelen 6 klinisch nicht kardial dekompensierte Patienten 5–7 Tage hindurch täglich 400 mg, 3 Patienten 200 bzw. 300 mg Spirolactone oral und 6 Patienten Placebo. Im Rahmen eines diagnostischen Herzkatheterismus wurden hämodynamische Messungen und multiple Serumkaliumbestimmungen vor und nach Gabe von 0,375–0,625 mg Strophanthin intravenös durchgeführt. Nach Strophanthin kam es zu einem signifikanten Abfall des enddiastolischen Drucks und zu einem Anstieg desdp/dt max im linken Ventrikel. In der Kontrollgruppe war ein signifikanter Anstieg der Kaliumspiegel im arteriellen und Koronarsinusblut zu beobachten, es bestand eine negative myokardiale Kaliumbilanz von der 3. bis zur 8. min nach Strophanthin. Die entsprechenden Werte nach Spirolactonevorbehandlung unterschieden sich von jenen der Kontrollgruppe nicht signifikant. Es wird geschlossen, daß nicht toxische Dosen von Strophanthin beim Menschen durch Hemmung der Natrium-Kalium-Membran ATPase zu einem myokardialen Kaliumverlust führen, der durch orale Vorbehandlung mit Spirolactone nicht sicher verändert wird.
    Notes: Summary In order to examine the question, whether improved digitalis tolerance by Spirolactone may be partially a result of antagonism on myocardial potassium balance, 6 patients without clinical signs of heart failure were given 400 mg, 3 were given 200 or 300 mg Spirolactone orally daily and 6 patients received placebo during a 5 to 7 days period. During cardiac catheterization hemodynamics and serum potassium concentrations were determined repeatedly prior to and following intravenous administration of 0,375 to 0,625 mg Strophanthin. Injection of Strophanthin resulted in a significant drop in left ventricular enddiastolic pressure and a rise indp/dt max. In the control group a significant increase in arterial and coronary sinus potassium concentration was observed. Myocardial potassium balance was definitely negative from the third to the eighth minute. Values in the group receiving Spirolactone did not differ significantly from the placebo group. It is suggested that therapeutic doses of Strophanthin result in a loss of potassium from the myocardium by inhibition of the Na+, K+ membrane ATPase not influenced by pretreatment with Spirolactone.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 121 (1993), S. 53-57 
    ISSN: 0942-0940
    Keywords: Supra-aortic vessels ; transluminal angioplasty ; intra-operative ; technique ; results
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Intra-operative transluminal angioplasty of supra-aortic vessels was performed in 9 patients. All subjects had lesions which were considered difficult or impossible to operate upon. In 2 patients a proximal occlusion of the left subclavian artery was dilated. Seven subjects showed severe stenoses of the supra-aortic vessels: common carotid artery: 1, internal carotid artery: 2, external carotid artery: 1, external carotid artery prosthetic graft: 1, brachiocephalic trunk: 1, vertebral artery: 1. All patients suffered from symptoms which corresponded to the site of the lesions in question. Intra-operative angioplasty was primarily successful in all 9 patients. Re-occlusion occurred within a few days in both patients who underwent angioplasty of the subclavian artery. Six of the seven subjets with stenotic lesions remained free of symptoms and of restenosis. In the case of dilatation of a prosthetic graft of the external carotid artery asymptomatic occlusion developed within 8 weeks. In selected cases intra-operative angioplasty is a potentially valuable alternative in the treatment of surgically inaccessible lesions of the supra-aortic vessels.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Intensive care medicine 22 (1996), S. 838-838 
    ISSN: 1432-1238
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Intensive care medicine 15 (1989), S. 478-479 
    ISSN: 1432-1238
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Annals of hematology 52 (1986), S. 365-370 
    ISSN: 1432-0584
    Keywords: Protein C ; Coumarin necrosis ; Thrombosis ; Anticoagulant therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Hemorrhagic skin necrosis of the toes was observed in a patient with heterozygous protein C deficiency (protein C:Ag 32% and protein C activity 30%) on the 4th day of coumarin treatment overlapping with effective intravenous anticoagulation with heparin. Family studies revealed protein C deficiency in two sisters of the proposita without a history of thromboembolic disease. Immunologic studies in the proposita at the time of coumarin necrosis revealed slight depression of complement factor C4 and the presence of immune complexes. The present case and review of the literature show that the pathogenetic mechanism leading to coumarin necrosis in patients with protein C deficiency seems not yet to be fully understood.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 6
    ISSN: 1432-1238
    Keywords: Percutaneous ; Dilational ; Tracheostomy ; Endoscopy ; Complications ; Minitracheostomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective To assess the value of endoscopic guidance in bedside percutaneous dilational tracheostomy. Design The medical critical care unit of a large community hospital. Setting 71 consecutive adult patients who required prolonged mechanical ventilation. Interventions 72 elective percutaneous dilational tracheostomies using the Ciaglia technique were performed under view of a flexible fiberoptic bronchoscope. Measurements and results Patients were examined during tracheostomy and on days 2 and 7 after the procedure, at discharge and after half a year if they were still alive. A correct median puncture was observed by endoscopic control in 59 interventions. an initial paramedian puncture was detected in 13/72 (18%) procedures and was corrected by renewed insertion in all cases. No severe complications related to percutaneous dilational tracheostomy were noticed. Minor complications occurred in 4/71 (5.6%) patients including minor bleeding in 2, inflammatory infiltration in 1 and one superficial lesion of the posterior tracheal mucosa. Long-term follow-up revealed stomal granulation in 3 patients including one at the tracheal site. At the end of the observation period the tracheostomy still was in use in 14/71 (20%) patients and 12/71 (17%) patients were decannulated. Due to their severe underlying diseases 45/71 (63%) patients had died. To facilitate weaning from the tracheostomy a minitracheostomy tube was used in 3 patients. Conclusion Percutaneous dilational tracheostomy is a simple bedside procedure associated with a low complication rate. We recommend the use of endoscopic guidance to increase the safety of tracheal puncture and dilation procedure.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Zeitschrift für Kardiologie 88 (1999), S. 442-447 
    ISSN: 1435-1285
    Keywords: Key words Atrial fibrillation – stroke – oral anticoagulation – acetyl salicylic acid ; Schlüsselwörter Vorhofflimmern – orale Antikoagulanzien – Azetylsalizylsäure – Schlaganfall
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Fragestellung: Ziel unserer Erhebung war es, zu erfassen, 1. wie vielen Patienten mit Vorhofflimmern eine antithrombotische Therapie bei der Entlassung aus österreichischen Krankenhausabteilungen empfohlen wurde; 2. ob Schlaganfall-/Embolie-Risikofaktoren (Alter 〉 65 Jahre, arterielle Hypertonie, Diabetes mellitus und früherer Schlaganfall) und Kontraindikationen für orale Antikoagulanzien (Demenz, Alkoholabusus) die Wahl der antithrombotischen Therapie beeinflußten und 3. ob zwischen den Krankenhausabteilungen Unterschiede bei der Therapieempfehlung bestanden. Patienten: Eingeschlossen wurden 1566 Patienten (841 Frauen 725 Männer, mittleres Alter 76 Jahre) mit permanentem oder paroxysmalem Vorhofflimmern und Herzinsuffizienz. Methoden: Bei Entlassung aus dem Krankenhaus wurden Schlaganfall-/Embolie-Risikofaktoren, Kontraindikationen und die empfohlene antithrombotische Medikation erfaßt. Ergebnisse: Orale Antikoagulanzien wurden 26 %, Azetylsalizylsäure (ASS) 31 %, eine Kombination von oralen Antikoagulanzien mit ASS 2 % und keine antithrombotische Therapie 41 % der Patienten empfohlen. Das Vorliegen von Schlaganfall-/Embolie-Risikofaktoren beeinflußte nicht die Wahl der antithrombotischen Therapie. Das Vorhandensein von Demenz, nicht aber von Alkoholabusus, beeinflußte die Empfehlung der antithrombotischen Therapie. Aus kardiologischen oder Rehabilitationsabteilungen entlassenen Patienten wurden häufiger orale Antikoagulanzien empfohlen als denen, die aus anderen Krankenhausabteilungen entlassen wurden. Konklusion: Unsere Ergebnisse zeigen, daß in der medizinischen Praxis die Empfehlungen für eine antithrombotische Therapie bei Vorhofflimmern zu selten berücksichtigt werden, insbesondere wenn zusätzliche Schlaganfall-/Embolie-Risikofaktoren vorhanden sind.
    Notes: Summary Objectives: To evaluate 1) how many patients with atrial fibrillation (AF) and heart failure were discharged from Austrian hospitals with antithrombotic therapy, 2) if the presence of risk factors for stroke/embolism (age 〉 65 years, arterial hypertension, diabetes, and previous stroke) influence the choice of antithrombotic therapy and if the presence of contraindications for oral anticoagulation (dementia, alcohol abuse) influence the choice of antithrombotic therapy, and 3) if there are differences among the types of departments in the use of antithrombotic therapy. Patients: Included were 1566 patients (841 female, 725 male, mean age 76 years) with AF and heart failure. Methods: at discharge, a questionnaire was completed including risk factors, contraindications for antithrombotic therapy, and antithrombotic medication. Results: Oral anticoagulants (OAC) had 26 % of the cases, acetyl salicylic acid (ASA) 31 %, a combination of OAC and ASA 2 %, and no antithrombotic therapy 41 %. The risk factors age 〉 65 years, arterial hypertension, diabetes, and previous stroke did not influence the choice of antithrombotic therapy. Dementia but not alcohol abuse influenced the choice against OAC. The rate of OAC was higher in cardiological or cardiovascular rehabilitation clinics than in other departments. Conclusion: The results of this survey show that in medical practice the recommendations regarding antithrombotic therapy in atrial fibrillation are rarely considered, especially when additional risk factors are present.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...