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  • 1
    Electronic Resource
    Electronic Resource
    Carbonyl-Related Posttranslational Modification of Neurofilament Protein in the Neurofibrillary Pathology of Alzheimer's Disease (1995)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 64 (1995), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: We present the first evidence for carbonyl-related posttranslational modifications of neurofilaments in the neurofibrillary pathology of Alzheimer's disease (AD). Two distinct monoclonal antibodies that consistently labeled neurofibrillary tangles (NFTs), neuropil threads, and granulovacuolar degeneration in sections of AD tissue also labeled the neurofilaments within axons of the white matter following modification by reducing sugars, glutaraldehyde, formaldehyde, or malondialdehyde. The epitope recognized by these two antibodies shows a strict dependency for carbonyl modification of the neurofilament heavy subunit. The in vivo occurrence of this neurofilament modification in the neurofibrillary pathology of AD suggests that carbonyl modification is associated with a generalized cytoskeletal abnormality that may be critical in the pathogenesis of neurofibrillary pathology. Furthermore, the data presented here support the idea that extensive posttranslational modifications, including oxidative stress-type mechanisms, through the formation of cross-links, might account for the biochemical properties of NFTs and their resistance to degradation in vivo.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.1995.64062660.x
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  • 2
    Electronic Resource
    Electronic Resource
    Low temperature relaxation of OH in the X 2Π and A 2Σ states in an argon free-jet (1999)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 110 (1999), S. 8555-8563 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: Low temperature (translational temperatures below 10 K) relaxation of OH in the X 2Π and A 2Σ states has been studied in an argon free jet. We determine upper limits on v=1 relaxation in the X 2Π manifold from laser induced fluorescence (LIF). We measure absolute relaxation rate coefficients for v=2(N), v=1(N), and v=0(N) levels in the A 2Σ state manifold. In addition, from comparison of the dispersed LIF we obtain state-to-state rate coefficients for v=1, N=0 and N=1 going to v′=0,N′ levels in the A 2Σ manifold. Bimolecular rate coefficients are reported which are all much greater than similar measurements at room temperature. Rates for vibrational relaxation at these low temperatures are 5.7(±0.7)×10−10 cm3/s for v(2−1) relaxation, 3.2(±1)×10−10 cm3/s for v(1−0) relaxation, and we report rotational relaxation rates for N=1 and 2 of v=0, 1 and 2 excited states, all near the collision limited values. © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.478763
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  • 3
    Electronic Resource
    Electronic Resource
    Induction of Heme Oxygenase-1 mRNA and Protein in Neocortex and Cerebral Vessels in Alzheimer's Disease (1995)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 65 (1995), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Previous studies demonstrated the specific association of heme oxygenase (HO)-1 protein to the neurofibrillary pathology of Alzheimer's disease (AD). In this study, we used reverse transcription-polymerase chain reaction methods to show the increased expression of HO-1 but not HO-2 mRNA transcripts in cerebral cortex and cerebral vessels from subjects with AD compared with age-matched non-AD controls. Neither the HO-1 nor the HO-2 mRNA level was altered in the cerebellum, a brain region usually spared from the pathological alterations of AD. There was no clear evidence that the expression of HO-1 in these tissues was related to postmortem interval, cause of death, or the age of the subjects studied. Using immunoblotting methods, we further showed that HO-1 protein content was increased in neocortical and vascular samples from AD subjects compared with controls. Our findings suggest the specific induction of HO-1 mRNA and protein in the cerebral cortex and cerebral vessels but not HO-2 mRNA or protein in association with the pathological lesions of the disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.1995.65031399.x
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  • 4
    Electronic Resource
    Electronic Resource
    Erratum: Direct observation of HSF+6 and the bracketing of the SF6 proton affinity at 5 K [J. Chem. Phys. 101, 3410 (1994)] (1994)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 101 (1994), S. 10197-10197 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.468518
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  • 5
    Electronic Resource
    Electronic Resource
    Free jet expansions of binary atomic mixtures: A method of moments solution of the Boltzmann equation (1995)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 103 (1995), S. 8638-8652 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The method of moments is used to obtain solutions to the Boltzmann equation describing flow and thermal relaxation of binary atomic mixtures undergoing adiabatic free jet expansion. Differential moment equations are solved within the framework of an anisotropic Maxwellian distribution function. Numerical integration of these equations yields the temporal dependence of the four moments of the distribution function for each flow component; density, hydrodynamic velocity, parallel temperature, and perpendicular temperature. Results are presented for mixtures of the rare gases which yield new insight into the driving forces behind the phenomena of velocity and temperature slip. The model can easily be extended to ternary and higher atomic mixtures. © 1995 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.470122
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  • 6
    Electronic Resource
    Electronic Resource
    Design and characterization of pulsed uniform supersonic expansions for chemical applications (1995)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 66 (1995), S. 4434-4446 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: A general formalism is presented for the production, characterization, and use of uniform supersonic flows for the study of structural and collisional molecular properties. These flows make possible the generation of thermally equilibrated gaseous environments at temperatures generally extending from near 10 to above 300 K at pressures between 0.1 and 10 Torr. In addition, the invariance of flow conditions for distances of many nozzle diameters (5–30) beyond the exit makes the flows ideal for collisional or temporal studies. A concise outline for the design of the Laval nozzles necessary to produce specified density and temperature conditions is presented. Pulsed operation of these expansions is demonstrated, and a variety of useful characterization tools providing information on flow uniformity and thermal characteristics is considered. Recent applications of these flows for the study of low-temperature chemical reactions are reviewed. © 1995 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1145338
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  • 7
    Electronic Resource
    Electronic Resource
    Two-color threshold photoionization of jet-cooled aniline: Vibrationally selective autoionization (1986)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 84 (1986), S. 6771-6780 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: We report the results of investigations of the autoionization of jet-cooled aniline-h7 and -d7. Using two-color photoionization techniques, we have observed autoionization of high lying Rydberg levels containing quanta of the nontotally symmetric vibrational modes 10b, I, and 15. No autoionization is observed for Rydberg states containing only totally symmetric vibrational excitation. In all of the spectra in which autoionization is found, the mechanism is vibrational–electronic coupling (vibrational autoionization) with a characteristic Δv=−1 propensity. An upper limit for the autoionization rate of 2×1012 s−1 has been determined from linewidth measurements. Possible explanations are presented and discussed for the activity of only nontotally symmetric vibrational modes in the autoionization process.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.450680
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  • 8
    Electronic Resource
    Electronic Resource
    Measurement of the autodetachment lifetime of SF6−* as a function of electron energy in a free jet expansion (2001)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 114 (2001), S. 8831-8835 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: A pure SF6 free jet expansion has been used for the measurement of the autodetachment lifetime of the resonant excited anion SF6−* as a function of electron energy in the range 0–100 meV. In this low temperature environment, the lifetime was found to be 19.1±2.7 μs and independent of electron energy. This result is consistent with earlier statistical modeling of this process in terms of a coupling to the bath of SF6− states which is only a smoothly varying function across the energy range spanned by the electron affinity plus the small variation in electron kinetic energy. The temperature dependence of the autodetachment lifetime also suggests a strong coupling of vibrational motion in SF6 with the autodetachment process consistent with the picture of nuclear excited Feshbach resonances. In addition, the rate coefficient for the very inefficient secondary stabilization rate of the SF6−* states on collision with SF6 neutrals below 10 K is determined to be 3±1×10−12cm3 s−1. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1368382
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  • 9
    Electronic Resource
    Electronic Resource
    Autoionizing Rydberg structure observed in the vibrationally selective, two-color, threshold photoionization spectrum of jet-cooled aniline (1985)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 83 (1985), S. 4820-4822 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: We report the observation of sharp autoionization structure in the two-color photoionization efficiency (PIE) spectrum of the I20 (1B2) band of jet-cooled aniline. The energy onset of this structure allows us to assign it to vibrational autoionization of high lying neutral Rydberg states with Δv=−1. Based on linewidth measurements, a lower limit of 0.5 ps can be set for the lifetime of these states.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.449010
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  • 10
    Electronic Resource
    Electronic Resource
    State-specific reactions HBr+(2Πi,v+)+(H2, HBr)→H2Br+ at low collisional energies (2001)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 114 (2001), S. 6625-6630 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: State-specific ion-molecule reactions of H-atom transfer between the HBr and H2 molecules with HBr+(2Πi,v+) were studied in a free jet flow reactor. The selected spin-orbit and vibrational states of the HBr+ ion were prepared by resonance-enhanced multiphoton ionization. All of the reactant and product ions were monitored using a time-of-flight mass spectrometer. Rate coefficients of the HBr+/H2 reaction vary from 〈2×10−12 cm3/s for the lowest spin-orbit-vibrational state to 2.1×10−11 cm3/s for the highest. Rates for the HBr+/HBr reaction are ∼1.5×10−9 cm3/s independent of the internal state of the ion. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1355661
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