ZIB

Hits per page

hits 1 - 2 | 2 hits

Sorting

Electronic Resource

Plasma β-Endorphin, Adrenocorticotropin Hormone, and Cortisol in Autism (1997)

Tordjman, Sylvie ; McBride, P. Anne ; Hertzig, Margaret E. ; [et al.]

Oxford, UK : Blackwell Publishing Ltd

The @journal of child psychology and psychiatry 38 (1997), S. 0

add to mindlist on the mindlist

Details

ISSN: 1469-7610

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine , Psychology

Notes: Plasma levels of the hypothalamo-pituitary-adrenal axis hormones β-endorphin (BE), adrenocorticotropin hormone (ACTH), and cortisol were measured in autistic (N= 48), mentally retarded/cognitively impaired (MR/CI, N= 16), and normal control (N= 26) individuals. Comparison of log transformed data from the three groups revealed that levels of BE and ACTH were significantly higher (p 〈 .05) in the autistic individuals than in normal controls. The higher means in the autistic group were due to significantly higher plasma levels of BE and ACTH, indices of acute stress response, in the more severely affected individuals. The data support the idea that individuals with severe autism have a heightened response to acute stressors rather than chronic hyperarousal or elevated basal stress response system functioning.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1469-7610.1997.tb01697.x

Permalink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

Electronic Resource

Plasma androgens in autism (1995)

Tordjman, Sylvie ; Anderson, George M. ; McBride, P. Anne ; [et al.]

Springer

Journal of autism and developmental disorders 25 (1995), S. 295-304

add to mindlist on the mindlist

Details

ISSN: 1573-3432

Source: Springer Online Journal Archives 1860-2000

Topics: Psychology

Notes: Abstract Plasma levels of testosterone and the adrenal androgen dehydroepiandrosterone sulfate (DHEA-S) were measured in male autistic subjects (31 prepubertal, 8 postpubertal), mentally retarded/cognitively impaired subjects (MR, 12 prepubertal), and normal control subjects (NC, 10 prepubertal, 11 postpubertal). Mean levels of plasma testosterone were similar in the postpubertal autistic (4.54+1.12 ng/ml) and postpubertal NC (5.02±1.87 ng/ml) groups. Plasma DHEA-S levels in postpubertal autistic (2170±1020 ng/ml) and postpubertal NC (1850±77 ng/ml) groups also were not significantly different. Similarly, no significant group differences were seen for testosterone or DHEA-S in the prepubertal autistic, MR, or NC individuals, although prepubertal MR individuals with cerebral palsy did have increased plasma DHEA-S levels compared to age-matched MR or NC individuals. Significant negative correlations were found between testosterone and whole blood serotonin (5-HT) levels in the combined (all subjects, all ages) groups and in the autistic group, suggesting that the effect of puberty on whole blood 5-HT may deserve further study. Data indicate that altered secretion of the androgens is not a common feature of autism. However, abnormalities of adrenal androgen secretion may be present in individuals with cerebral palsy.