ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Sequential single frequency decoupling and partially relaxed Fourier transform (PRFT) are used to assign the natural abundance 13C-NMR. spectra of cytochalasin B (phomin) (1) and cytochalasin D (2). Cultures of Phoma spec. S 298 were fed [2-13C]-sodium acetate, and the distribution of this precursor in cytochalasin B (phomin) (1) was determined by 13C-NMR. spectroscopy. Likewise, the labelling patterns in cytochalasin D (zygosporin A) (2) from Zygos-posium masonii could be identified after incorporation of [2-13C]-sodium acetate and [l-13C]-sodium acetate. The results confirm previous proposals for the biogenesis of the cytochalasans from phenylalanine, methionine, and a C18, or C16, polyketide part.
Additional Material:
7 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19740570630
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