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  • 1
    Electronic Resource
    Electronic Resource
    Adjuvant chemotherapy for locally advanced bladder cancer (1985)
    Springer
    World journal of urology 3 (1985), S. 115-120 
    Details
    ISSN: 1433-8726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Although controversy over the relative efficacy of full-dose pelvic radiation and radical cystectomy, with or without pre-operative radiation, continues, none of these treatments directed only at the disease in the pelvis cures more than 50 percent of patients with locally advanced disease. An effective systemic therapy is needed. The most effective single agent in metastatic bladder cancer, Cis-platin, has not altered the cure rate when used as an adjuvant. Limited trials using Cis-platin based three and four drug combination chemotherapy regimens have yielded 50–70 percent overall response rates with 30 percent complete responses in metastatic disease. It seems appropriate to perform pilot studies using these more intensive programs as adjuvant chemotherapy for good performance status patients at high risk of progression, e.g. positive lymph nodes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00326719
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Urothelial trauma — A mechanism of tumor promotion? (1983)
    Springer
    World journal of urology 1 (1983), S. 100-102 
    Details
    ISSN: 1433-8726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Multistage carcinogenesis involves both tumor initiation and promotion. This study was undertaken to investigate whether urothelial trauma is an effective promoting agent. One hundred and ninety mice were maintained on a diet of 0.1% FANFT. Forty animals served as controls and three groups of animals underwent bladder catherization and urothelial trauma at periodic intervals beginning at week 19. The experiment was terminated at week 49. The data revealed no significant difference in the incidence of tumors in any group. There was, however, a greater incidence of invasive tumors in the groups undergoing urothelial trauma (Group II, 30%; Group III, 39%; Group IV, 57%) compared with the controls (25%). Trauma may, therefore, have some role in the promotion of tumors. Further studies are in progress to better define the role of urothelial trauma and its possible relevance to clinical recurrence of transitional cell carcinoma following transurethral resection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00326753
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The role of nuclear matrix protein 22 in the detection of persistent or recurrent transitional-cell cancer of the bladder (1997)
    Springer
    World journal of urology 15 (1997), S. 107-111 
    Details
    ISSN: 1433-8726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Successful management of transitional-cell carcinoma of the urinary bladder is greatly dependent upon regular surveillance and early detection of persistent or recurrent carcinoma. The development of a highly sensitive urinary test for the detection of transitional-cell carcinoma of the bladder could have a dramatic impact on our ability to diagnose and monitor bladder cancer patients as well as influence the treatment outcome. The urinary level of the nuclear matrix protein, NMP22, has been found to be elevated in patients with urothelial malignancy. This has prompted the development of an immunoassay to quantitate urinary NMP22 and use it as a cancer-specific marker. We provide a summary of the studies completed with the immunoassay for urinary NMP22 as an indicator for the presence of transitional-cell carcinoma and compare the results with those obtained using other screening modalities.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02201981
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Transitional cell carcinoma of the prostate: Diagnosis, staging and management (1988)
    Springer
    World journal of urology 6 (1988), S. 170-174 
    Details
    ISSN: 1433-8726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Over a 5-year period, 21 patients were diagnosed with transitional cell carcinoma (TCC) of the prostate. Tumor was primary to the prostate in 3 patients, but was associated with TCC of the bladder in the remaining 18. Ten patients developed TCC of the prostate following intravesical therapy for TCC of the bladder. Patients were staged according to local tumor extent, with 2 having disease confined to the prostatic urothelium, 7 showing invasion into ducts and 12 with stromal involvement. None of the 21 patients had metastatic disease at diagnosis. A total of 14 patients underwent radical cystoprostatectomy as primary therapy, while the remaining 7 were managed without radical surgery, receiving intravesical therapy, transurethral resection, systemic chemotherapy, and radiotherapy, singly or in combination. Minimum follow-up was 22 months, with an average of 35 months. Twelve patients (57%) are alive with no evidence of disease, 3 (14%) are alive with tumor and 6 (29%) have died — 5 (24%) of progressive tumor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00326796
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Superficial bladder cancer: Diagnosis, surveillance and treatment (1992)
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 50 (1992), S. 120-127 
    Details
    ISSN: 0730-2312
    Keywords: intravesical therapy ; superficial bladder cancer ; transitional cell carcinoma ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Approximately 70% of all bladder cancers are superficial at the time of presentation. Superfecial bladder cancer includes tumors confined to the urothelium (clinical stage Ta) or lamina propria (stage T1) and flat carcinoma is situ (stage Tis). Because the biological behavior of bladder neoplasms is variable, several important prognostic factros must be addressed. Multivariate analyses have shown that factors predictive of tumor recurrence and tumor progression include multifocal tumors, high grade tumors. T1 tumors and positive urinary cytology after transurethral resection (TUR). The patient with superficial bladder cancer should be monitored via endoscopy supplemented by urinary cytology, using either voided or bladder irrigation specimens and urinalysis. Frequent intravenous urography is not required, even in high grade tumors, as long as the clinical and pathologic studies remain negative and the patient is asymptomatic.The “gold standard” of treatment for superficial is TUR of the entire tumor. Despite TUR, new tumors will occur in approximately 50% of all patients; those at highest risk for tumor recurrence and progression require adjuvant intravesical therapy after TUR. A variety of drugs are used as intravesical therapy, including thiotepa, mitomycin C, doxorubicin hydrochloride, Bacillus Calmette-Guerin (BCG), epirubicin, and interferon. Although associated with the most toxicity, BCG appears to be the most effecacious agent in increasing the time to recurrence and progression and in reducing the recurrence rate. © 1992 Wiley-Liss, Inc.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcb.240501323
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    Paper (German National Licenses)
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