ISSN:
1619-7089
Keywords:
Gastrointestinal scintigraphy
;
99mTc-DTPA
;
Labeled tablets
;
Pharmacokinetics
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The in vitro and in vivo dissolution of a sustained release theophylline formulation labeled with 99mTc-diethyltriaminepentaacetic acid (DTPA) has been monitored in six subjects with a scintillation camera. The study was performed in fasting conditions and was repeated after ingestion of a standardized meal. Results showed that the presence of food in the stomach dramatically increased the oesoduodenal transit time of the tablet (74±27 min vs 352±77 min, P〈0.001) but did not modify the biodisponibility of theophylline. This study is another example when scintigraphy can be of definite value in pharmacokinetics.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00254627
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