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  • 1
    Electronic Resource
    Electronic Resource
    In allergic asthma experimental exposure to allergens is associated with depletion of blood eosinophils overexpressing LFA-1 (2002)
    Oxford, UK : Munksgaard International Publishers
    Allergy 57 (2002), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: In atopic individuals, exposure to allergens is followed by recruitment of blood eosinophils in the target tissue. We investigated whether allergen inhalation challenge could result in depletion of blood eosinophils overexpressing adhesion molecules involved in eosinophil migration.Methods: Blood eosinophils were isolated from seven atopic asthmatic patients and seven control subjects and the “at baseline” expression of lymphocyte function-associated antigen-1 (LFA-1), macrophage antigen-1 (Mac-1) and very late antigen-4 (VLA-4) was assessed by monoclonal antibody staining and flow cytometry analysis. Asthmatic patients underwent allergen challenge and the expression of LFA-1, Mac-1 and VLA-4 by blood eosinophils was again evaluated 3 h and 24 h after allergen challenge.Results: As compared to controls, eosinophils from atopics showed at baseline enhanced LFA-1 expression (P=0.0012), but similar Mac-1 or VLA-4 expression (P 〉 0.1, each comparison). In atopics, the percentage and absolute number of blood eosinophils were significantly decreased 3 h after allergen challenge (P=0.001 and P=0.022, respectively) but returned to similar values to prechallenge values after an additional 21 h (P 〉 0.1). Allergen challenge was also followed by a significant decrease in LFA-1 expression by eosinophils, at 3 h (P=0.002) and at 24 h (P=0.038), while no changes in Mac-1 and VLA-4 were observed. A significant correlation between postchallenge decrease in LFA-1 expression and in blood eosinophilia, both expressed as percentage (r=0.88; P 〈 0.01) or absolute number (r=0.87; P 〈 0.01) was demonstrated at 3 h (r=0.88; P 〈 0.01) but not at 24 h (r=0.64, P 〉 0.05 and r=0.11; P 〉 0.05, respectively).Conclusion: In allergic asthma, an early recruitment of blood eosinophils overexpressing LFA-1 occurs in the first hours after allergen challenge.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1034/j.1398-9995.2002.23826.x
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  • 2
    Electronic Resource
    Electronic Resource
    The 1997 Umbria-Marche (Italy) earthquake sequence: analysis of the data recorded by the local and temporary networks (2000)
    Springer
    Journal of seismology 4 (2000), S. 401-414 
    Details
    ISSN: 1573-157X
    Keywords: Aftershocks distribution ; Apennines ; earthquake location ; propagation models ; seismic sequences
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract We present some preliminary results obtained from thejoined analysis of the data collected by the permanentand the temporary networks operating in the area ofthe earthquake sequence that followed (andanticipated) the 26 September, Central Italy, mainshocks. In particular, these earthquake data haveallowed us to determine a well constrainedwave-velocity model (both P and S) with stationcorrections which demonstrated to produce robusthypocentral locations. These velocity modelswith station corrections have been used forre-locating the whole September 1997–July 1998subset of data of the permanent network, and theprevious background seismicity, starting from May1996. The focal mechanisms of the largest events werealso obtained from an analysis of the first-motionpolarities.Our results indicate that 1) the seismic activityaligns on a SE-NW trend for a total length of about50 km of extension; 2) the focal depth of theseevents is restricted to the range 0–9 km; 3) mostevents can be related to sub-parallel SW dipping faultplanes; 4) focal mechanisms of the largest shocks(ML 〉 4) show a coherent behaviour, withnormal fault solution on SSE-NNW striking, SW dippingplanes; 5) the space-time evolution of the activitydisplays a discontinuous mode of energy release, withdifferent episodes of activation and an apparentclustering of aftershocks at the edges of the areaswhich presumably ruptured in the main shocks.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1026511209166
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  • 3
    Electronic Resource
    Electronic Resource
    The 1997 Umbria-Marche (Italy) earthquake sequence: Tomographic images obtained from data of the GNDT-SSN temporary network (2000)
    Springer
    Journal of seismology 4 (2000), S. 415-433 
    Details
    ISSN: 1573-157X
    Keywords: Apennines ; local earthquake tomography ; seismicity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract We present some preliminary images of the 3-D P-wavevelocity model and of the relocated seismicityobtained from the data collected by the GNDT-SSNtemporary network installed in the epicentral area ofthe earthquake sequence that followed the 26September, 1997, Central Italy main shock(Mw = 6.0). This network consisted of a total of 15stations, was deployed in the southern part of thearea affected by the earthquake sequence and operatedfor a total of 17 days starting on 10/18/97.Our results indicate that 1) the P-velocity structuredisplays a pattern of lateral variations consistentwith the general NW-SE trend of the Apennines in thearea; 2) the aftershock foci distribute, in thesouthern part of the sequence, on distinct and welldefined SW dipping planes which surface intersectionsmatch previously recognized active normal faults; 3)a distinct zone of aftershock quiescence is observedin correspondence of the 10/12 (ML = 5.3) and10/14/97 (ML = 5.7) hypocenters near Sellano; 4)the seismicity at the southern end is very shallow andit is unclear the relationship between the 1997 andthe 1979 Norcia sequences.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1026575325837
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  • 4
    Electronic Resource
    Electronic Resource
    A Waveform Similarity Approach to Investigate Seismicity Patterns (1999)
    Springer
    Natural hazards 19 (1999), S. 123-138 
    Details
    ISSN: 1573-0840
    Keywords: cross-correlation ; similarity ; cluster ; earthquake family ; doublet ; multiplet ; western alps
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Geography , Geosciences
    Notes: Abstract the temporal and spatial evolution of seismicity, a simple cross-correlation technique was applied to a waveform data set of western Alps earthquakes. A selection of events recorded by a reference station of the regional seismic network of North-Western Italy (IGG network) within a particular S-P range was used. The adopted method was tested on 380 events recorded in 1995, allowing for the definition of the critical parameters for an optimal identification of earthquake families. The comparison of the individuated families definition with the relevant epicentres map confirms that, on small scales, the epicentre positions of microearthquakes located by a regional network could be strongly influenced by location errors. The analysis was extended to a more complete data set of 2653 events; 1171 of them were grouped in families. The results demonstrated that our single station method is able to discriminate between closely spaced families on the basis of the position and of the radiation properties.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008099705858
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    Paper (German National Licenses)
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