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  • 1
    Electronic Resource
    Electronic Resource
    Established cell lines for safety assessment of food contaminants: Differing furazolidone toxicity to V 79, HEp-2 and Caco-2 cells
    Amsterdam : Elsevier
    Food and Chemical Toxicology 32 (1994), S. 481-488 
    Details
    ISSN: 0278-6915
    Keywords: [abr] CEC; Commission of the European Communities ; [abr] DMSO; dimethyl sulfoxide ; [abr] EEC; European Economic Community/Commission ; [abr] FRAME; Fund for the Replacement of Animals in Medical Experiments ; [abr] FZ; furazolidone ; [abr] GI; gastro-intestinal ; [abr] IARC; International Agency for Research on Cancer ; [abr] LDH; lactate dehydrogenase ; [abr] MEIC; Multicenter Evaluation of In Vitro Cytotoxicity ; [abr] PBS; phosphate buffered saline
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0278-6915(94)90046-9
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  • 2
    Electronic Resource
    Electronic Resource
    Furaltadone cytotoxicity on three cell lines in the presence or absence of DMSO: Comparison with furazolidone (1997)
    Springer
    Cell biology and toxicology 13 (1997), S. 125-130 
    Details
    ISSN: 1573-6822
    Keywords: cytotoxicity ; DMSO ; nitrofurans
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Nitrofuran drugs have been studied on cellular systems in order to develop in vitro tests for safety assessment of food contaminants. In the present study we have tested furaltadone on three cell lines (HEp-2, Caco-2 and V79), using the same toxicity endpoints as in a previous study with furazolidone, namely cell viability and growth, colony-forming ability, LDH release, and O2 consumption. One of the aims of this investigation was to compare the two compounds in order to determine whether our models are able to discriminate among structurally related molecules. The other aim was to study the influence of the solvent used on the observed toxicity, because furaltadone is soluble both in water and in DMSO. The results show that the three cell lines used are differently affected by the two compounds, and that, at least in the case of furaltadone, the solvent is not relevant for the observed toxicity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/B:CBTO.0000010397.26120.4d
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  • 3
    Electronic Resource
    Electronic Resource
    Apoptosis evaluation in epithelial cells exposed to different chemicals: relevance of floating cells (2000)
    Springer
    Cell biology and toxicology 16 (2000), S. 53-62 
    Details
    ISSN: 1573-6822
    Keywords: apoptosis ; cell adhesion ; cytotoxicity tests ; epithelial cells ; morphology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The recent increase in understanding of cell death has promoted new approaches in toxicological studies, mainly those dealing within vitro systems where the evaluation of cell death has been the most widely adopted end-point in measuring the effects of chemical toxicants. The aim of this study was to investigate the possibility of improving the traditional cytotoxicity test protocols in order to produce more specific information on the type of cell death induced by exposure to toxicants. In particular, we characterized the mode of cell death in an established epithelial cell line, HEp-2 cells, which is frequently used in cytotoxicity testing owing to its easy handling and standardization of culture conditions. Reference chemicals for apoptosis and necrosis were selected as controls, together with other molecules that have been shown, in preliminary studies, to induce various morphological and structural modifications in relation to cell death. The results obtained show that: (a) the floating fraction of treated cells gives the clearest picture of the necrotic/apoptotic distribution; (b) morphological analysis is crucial for characterization of apoptosis; (c) more than one cytotoxic end-point is necessary to clearly identify the type of cell death.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1007696604725
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    Paper (German National Licenses)
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