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  • 1
    Electronic Resource
    Electronic Resource
    The effects of topical nasal steroids on rat respiratory mucosa in vivo, with special reference to benzalkonium chloride (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 52 (1997), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Fifty rats were treated with topical nasal steroids with and without the preservative benzalkonium chloride in their right nostril twice daily for 21 days, while the left nostrils were exposed to 0.9% NaCl. By cutting the noses serially in frontal sections, the structure of the mucosal lining of all parts of the nose could be investigated. Areas with squamous cell metaplasia were observed in all nostrils exposed to topical steroids containing benzalkonium chloride. Such alterations were not observed in any nasal cavities exposed to the topical nasal steroid without the preservative or to 0.9% NaCl. In conclusion, benzalkonium chloride appears to be potentially toxic to the mucosa in vivo.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.1997.tb01041.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Fetal rat brain hemisphere tissue in nonadherent stationary organ culture (1985)
    Springer
    Cellular and molecular life sciences 41 (1985), S. 1517-1524 
    Details
    ISSN: 1420-9071
    Keywords: Rat brain fragments ; stationary ; nonadherent organ culture ; cell differentiation and migration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A simple organ culture system for brain tissue is described. Fragments of fetal rat brain hemisphere tissue are explanted to multiwell dishes base-coated with semisolid agar. In this system nonadherent organ culture can be performed for at least 50 days. Cell migration, biochemical and morphological differentiation and the formation of a layered architecture seem to mimic some of the phenomena occurring in the developing rat brain in vivo. The fragments may therefore be a useful organ culture model for nervous tissue.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01964788
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Ultrastructural investigation of fetal rat brain hemisphere tissue in nonadherent stationary organ culture (1986)
    Springer
    Cellular and molecular life sciences 42 (1986), S. 798-803 
    Details
    ISSN: 1420-9071
    Keywords: Nonadherent organ culture ; rat brain tissue ; ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Fetal rat brain fragments grown in nonadherent stationary organ culture for 50 days have been investigated ultrastructurally. Synaptogenesis and myelin formation occurred at the same time as the corresponding time-dependent events in the developing brain in vivo. Intermediate junctions were observed between cellular processes lining a central cavity in the fragments and later associated with astrocytes at the surface. Gap junctions and tight junctions were also present. In some fragments cilia were observed in the central cavity. Subependymal basement membrane labyrinths were observed in all fragments after 10 days in culture. The ultrastructural characteristics and the tissue-like structure in general were preserved for at least 50 days in this tissue culture system. The brain fragments may therefore be a valuable supplement to existing culture methods for nervous tissue.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01941528
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    Paper (German National Licenses)
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