Electronic Resource
Palo Alto, Calif.
:
Annual Reviews
Annual Review of Genomics and Human Genetics
6 (2005), S. 261-286
ISSN:
1527-8204
Source:
Annual Reviews Electronic Back Volume Collection 1932-2001ff
Topics:
Biology
Notes:
Chemical genetics is an emerging approach for studying biological systems using chemical tools. This strategy aims to reveal the macromolecules responsible for regulating biological systems; thus, the approach shares much in common with genetics. In both strategies, one must (a) develop an assay that reports on a biological process of interest, (b) perturb this process systematically (with mutations or small molecules), and (c) determine the target of each perturbation to reveal macromolecules (i.e., proteins and genes) regulating the process of interest. In this review, we discuss advances and challenges in this field that have emerged over the past four years. Several technologies have converged, raising the hope that it may be possible to systematically apply chemical probes to biological processes.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1146/annurev.genom.6.080604.162136
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