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  • 1
    Electronic Resource
    Electronic Resource
    The effect of spironolactone on experimental periodontitis in rats (2005)
    Oxford, UK : Munksgaard International Publishers
    Journal of periodontal research 40 (2005), S. 0 
    Details
    ISSN: 1600-0765
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background:  Elevated levels of tumour necrosis factor (TNF) have been found in patients with adult periodontitis. Animal studies have shown that TNF plays an important role in the pathogenesis of periodontitis. New findings suggest that the aldosterone-inhibitor spironolactone possesses an anti-TNF effect. The purpose of the study was to determine the anti-TNF effect of spironolactone in an endotoxic shock rat model and to disclose the effect of oral administration of spironolactone on the development of experimental periodontitis in rats.Methods:  The study was divided in two parts. Part 1: oral administration of spironolactone (100 mg/kg) followed by intravenous lipopolysaccharide (1 mg/kg) infusion 45 min later. Blood samples were taken before and 90 min after lipopolysaccharide infusion to determine the TNF levels in spironolactone treated and non-treated rats. Part 2: oral administration of spironolactone [100 mg/(kg day)] starting 2 days prior to induction of experimental periodontitis established by peridental ligatures. Morphometrical and radiographical registrations of alveolar bone destruction were carried out to determine the effect of spironolactone on the progression of experimental periodontitis.Results:  In part 1 the endotoxic shock model showed a significant reduction in TNF levels in the spironolactone-treated group compared to the non-treated group, suggesting that spironolactone acts as a TNF inhibitor. In part 2 spironolactone-treated rats did not demonstrate significantly less alveolar bone destruction compared to non-treated rats.Conclusions:  The insignificant effect of spironolactone treatment could be explained by the fast metabolism of spironolactone and that spironolactone does not completely inhibit TNF production in rats. Moreover, many other cytokines and mediators involved in alveolar bone destruction may account for the lacking response to spironolactone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0765.2005.00792.x
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  • 2
    Electronic Resource
    Electronic Resource
    Dynamic and static recordings of the comfortable zone (1978)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral rehabilitation 5 (1978), S. 0 
    Details
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A dynamic and a static method of assessing the comfortable zone by means of a screw jack were compared in 12 subjects. Recorded under dynamic conditions the average width of the comfortable zone was approximately 3·0 mm, and under static conditions approximately 5·0 mm (P 〈 0·0001). It is suggested that in the dynamic experiments the larger output from receptors in the chewing system was responsible for the narrower zone, i.e. the more precise assessments of the comfortable zone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2842.1978.tb01207.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Horizontal stabilization of upper and lower borders of the comfortable zone (1978)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral rehabilitation 5 (1978), S. 0 
    Details
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Using a screw jack device the upper and lower borders of the comfortable zone were recorded in a two step procedure designed to counteract bias inherent in previous measurements. In these measurements, successively increasing and decreasing values of zonal borders were recorded corresponding to a fully closed or fully opened starting position of the screw. Both of these positions are outside the comfortable zone. The two step procedure used a starting position which was supposed to lie inside the comfortable zone. However, the procedure did not achieve its aim fully. It succeeded only in stabilizing the lower border values. In the discussion hypothetical considerations are made concerning theneurophysiological mechanism underlying recordings of the borders of the comfortable zone, which might explain the differential behaviour of the zonal borders.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2842.1978.tb00385.x
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  • 4
    Electronic Resource
    Electronic Resource
    Concatenation of variations in plaque formation with variations in crevicular temperature (1980)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral rehabilitation 7 (1980), S. 0 
    Details
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The hypothesis was tested that variations in the temperature of gingival crevices are linked to variations in plaque formation. Fifty-nine abutment teeth to removable partial dentures were studied during four experiments, under various conditions of plaque formation, i.e. not brushing the teeth whilst wearing and not wearing dentures, and performing ordinary and then specialized tooth brushing whilst wearing dentures. The collation of temperature curves with plaque curves revealed a proportional relationship between the rate and magnitude of plaque formation and the rate and magnitude of the recorded temperature changes. Furthermore, the removal of plaque resulted in a reversal of induced temperature rises. The lowest crevicular temperatures were obtained with the practice of the specialized tooth brushing.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2842.1980.tb00436.x
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  • 5
    Electronic Resource
    Electronic Resource
    The linear model: a statistical tool applied to psychophysical research in dental prosthetics (1976)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral rehabilitation 3 (1976), S. 0 
    Details
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The construction of a linear model is described, and its function in analysing variations in the perception of comfortable mandibular occlusal positions is explained. In principle, the model combines analyses of variance and regression in a number of simple computer operations. Data from a clinical study were used to demonstrate the analytical capacity of a specific model, designed to estimate the effect of factors, which were supposed to influence the perception of comfortable mandibular positions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2842.1976.tb01454.x
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  • 6
    Electronic Resource
    Electronic Resource
    Crevicular temperature rises stimulated by plaque formation (1979)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral rehabilitation 6 (1979), S. 0 
    Details
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In nineteen subjects, temperatures were recorded thermo-electrically in the vestibular and proximal crevices of fifty-nine teeth. It was found that the formation of a new plaque was followed by a rise in crevicular temperature. In addition, it was found that the normal as well as the abnormal crevicular temperatures were higher in the mandible than in the maxillae.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2842.1979.tb01500.x
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  • 7
    Electronic Resource
    Electronic Resource
    Does a temperature gradient exist across the mucogingival junction? (1978)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral rehabilitation 5 (1978), S. 0 
    Details
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: On the assumption that the colour difference between attached gingiva and alveolar mucosa is accompanied by a temperature difference, twenty subjects with a high standard of oral health were studied. Five points on either side of the mucogingival junction were examined by means of a thermocouple probe. A mean difference amounting to about 2/3°C was found between the surface temperatures of the two structures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2842.1978.tb00394.x
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  • 8
    Electronic Resource
    Electronic Resource
    A new intra-oral screw jack (1977)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral rehabilitation 4 (1977), S. 0 
    Details
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A new pattern of screwjack for assessing the vertical dimension for occulusion utilizing an edentulous patient's proprioceptive sensation is described. It provides a greater range of movement than other, giving infinitely variable heights between 9 and 21 mm. The elements being captive, it cannot come to pieces in use.Laboratory experiments were contrived to define the magnitude of reading errors and the play in the screw threads. It was found that, only in instances where a graduation related closely to the datum mark, did errors of interpretation arise. These were found to exceed the height set for test purposes by 0·1 mm consistently. An error of this order is of no practical significance clinically and is no impediment to such an application of the device. Mean play in the new pattern jacks was 0·01 mm compared to 0·05 mm in the Timmer versions.In a clinical experiment the performance of the screw was compared to that of Timmer. Statistical evidence was found which suggested a functional difference between the two, the new pattern being significantly more accurate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2842.1977.tb00973.x
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  • 9
    Electronic Resource
    Electronic Resource
    Short-term changes in the perception of comfortable nandibular occlusal positions (1977)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral rehabilitation 4 (1977), S. 0 
    Details
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In search of a new clinical method for determining the occlusal height of full dentures, the perception of the comfortable zone was studied in fifteen edentulous patients. In each experimental session perceptual changes were recorded from forty-four consecutive applications of a screw jack per subject. Two stages in perceptual acuity were found. An initial stage, in which only minor variations occurred among the final screw adjustments which the subjects made when they assessed the borders of the comfortable zone. In the ensuing stage greater variations emerged, indicating a deterioration in the ability of the subjects to disciminate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2842.1977.tb00958.x
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    Paper (German National Licenses)
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  • 10
    Electronic Resource
    Electronic Resource
    Effect of toothbrush stimulation on temperature of gingival and alveolar mucosae (1980)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral rehabilitation 7 (1980), S. 0 
    Details
    ISSN: 1365-2842
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Thermometry was used to study the effect of applying a toothbrush to three types of oral mucosae, in forty dental students. Brushing with an electric tooth brush resulted in an immediate fall in temperature, but 3 min later the temperature was significantly higher than before stimulation. The temperature changes were greater in gingival crevice and attached gingiva compared with alveolar mucosa. Moreover, it was found that a static application of the toothbrush produced temperature changes which were equal to those following a dynamic application.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2842.1980.tb00424.x
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