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  • 1
    Electronic Resource
    Electronic Resource
    Fungal allergy in children (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Pediatric allergy and immunology 1 (1990), S. 0 
    Details
    ISSN: 1399-3038
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: One hundred and thirty-nine children (85 hoys) from a paediatric allergy clinic were included in a study which aimed to relate disease traits of fungal allergy to measured serum IgE antibodies to fungi. A structured case history was recorded and the children were subject to a panel of skin prick tests which included common inhalant allergens and two fungi, Cladosporium herbarum and Alternoria alternata. Serum IgE antibodies to 16 different fungi were assayed by RAST using the Pharmacia extended panel. Forty-seven of the children were positive to fungal RAST and many of them were positive to multiple fungi. C. herbarum gave the highest frequency of positive results. The best combination of three fungi for detecting fungal sensitization was C. Herbarum, Penicillium notatum and Mucor racemosus. Skin prick test (SPT) failed to uncover fungal sensitization in many children with broad RAST sensitivity. Children with RAST positivity to fungi generally had more severe asthma and more frequently recognised summer and autumn to be a difficult period compared with children without such positivity. In stepwise regression analysis, positive SPT for cat had the best explanatory value for asthma and positive C. herbarum RAST the second best. Children with fungal RAST positivities were not over-represented among cases with allergic rhino-conjunctivitis but there was a strong association to eczema. The latter is possibly explained by concomitant sensitization to fungi colonizing the human skin. It is suggested that the identification of fungal allergy in asthmatic children will help ensure that proper anti-inflammatory treatment is instituted during peak spore periods.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1399-3038.1990.tb00013.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Topical sodium cromoglycate (Opticrom®) relieves ongoing symptoms of allergic conjunctivitis within 2 minutes (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 49 (1994), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Montan P, Zetterström O, Eliasson E, Strömquist L-H. Topical sodium cromoglycate (Opticrom®) relieves ongoing symptoms of allergic conjunctivitis within 2 minutes.Twelve patients with seasonal allergic conjunctivitis caused by either birch or timothy grass pollen were challenged out of season in both eyes, with the relevant allergen. Itching, redness, swelling, and tearing were assessed on a 0–3 scale. When a positive reaction, i.e., at least 4 points, had occurred in both eyes, one drop of 2% sodium cromoglycate was administered to one eye and one drop of placebo to the other eye in each patient, in a double-blind, randomized fashion. Symptoms were then assessed after 2, 10, 30, and 60 min. Sodium cromoglycate was statistically better than placebo in reducing the symptoms at 2, 10, and 30 min after the treatment had been administered, showing that topical application of 2% sodium cromoglycate can quickly relieve ongoing symptoms of allergic inflammation in the eve.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.1994.tb00132.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Sodium cromoglycate as a replacement for inhaled corticosteroids in mild-to-moderate childhood asthma (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 51 (1996), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We investigated whether sodium cromoglycate 10 mg three times daily, delivered as an aerosol via Nebuhaler (in addition to terbutaline 0.5 mg three times daily), could replace inhaled steroid in children with mild-to-moderate asthma. Children (mean age 10.3 years) were randomly allocated to 12-week treatment with sodium cromoglycate 10 mg plus terbutaline 0.5 mg (group A; n= 30) or placebo plus terbutaline 0.5 mg (group B; n= 32), both taken three times a day. The daily steroid dose was reduced by 50 μg/week for 4 weeks from a starting dose of 200 μg. Fewer patients withdrew owing to worsening asthma from group A (n= 1) than group B (n = 11). Symptom scores, morning and evening peak flows, and additional β2-agonist usage, recorded on diary cards, were better in group A than group B. Lung function measured at clinic visits was unchanged in either group. Overall opinions of efficacy favoured Group A. Adverse events were similar in the groups. Sodium cromoglycate plus terbutaline substituted effectively for inhaled steroid therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.1996.tb04486.x
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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