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  • 1
    Electronic Resource
    Electronic Resource
    Intracellular application of polyamine and polyamine amide inhibits the quisqualate-sensitive ionotropic glutamate receptor of locust (Schistocerca gregaria) muscle (1997)
    Springer
    Invertebrate neuroscience 2 (1997), S. 223-233 
    Details
    ISSN: 1439-1104
    Keywords: philanthotoxins ; patch clamp ; locust muscle ; ionotropic glutamate receptor ; intracellular injection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The effects of intracellularly-applied philanthotoxin-343 (PhTX-343) on single channel currents gated by quisqualate-sensitive glutamate receptors (qGluR) of locust leg muscle have been studied. PhTX-343 initially increased qGluR channel open probability, mainly by virtue of an increase in mean channel open time, but this was followed by a decrease in channel open probability, sometimes to zero, because of a decline in the frequency of channel openings and a decline in mean channel open time. These results suggest that antagonism of qGluR by PhTX-343 can arise, in part, through binding of the toxin to a site or sites on the intracellular domain of this receptor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02211935
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The action of philanthotoxin-343 and photolabile analogues on locust (Schistocerca gregaria) muscle (1995)
    Springer
    Invertebrate neuroscience 1 (1995), S. 159-172 
    Details
    ISSN: 1439-1104
    Keywords: glutamate receptors ; locust muscle ; photolabile philanthotoxins ; voltage clamp ; patch clamp
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The effects of philanthotoxin-343 (PhTX-343; tyrosyl-butanoyl-spermine) and photolabile analogues of this synthetic toxin on locust (Schistocerca gregaria) skeletal muscle have been investigated using whole muscle preparations (twitch contractions), single muscle fibres (excitatory postsynaptic currents (EPSCs)) and muscle membrane patches containing single quisqualate-sensitive glutamate receptors (qGluR). Analogues containing an azido group attached to either the butanoyl side-chain of PhTX-343 or as a substitute for the hydroxyl moiety of the tyrosyl residue were about 6 fold more potent antagonists than PhTX-343; those with an azido group located at the distal end of the toxin molecule were generally 2–3 fold less potent than PhTX-343. When these compounds were tested in subdued light, they were reversible antagonists of the muscle twitch, EPSC and qGluR. When a muscle was irradiated with U.V. during application of photolabile toxin combined with either neural stimulation of the muscle orl-glutamate application, antagonism of the twitch, EPSC and qGluR was complete and irreversible.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02331913
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The determination of nivacortol in plasma using HPLC (1986)
    New York, NY : Wiley-Blackwell
    Biomedical Chromatography 1 (1986), S. 151-154 
    Details
    ISSN: 0269-3879
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: A high performance liquid chromatographic method with ultraviolet detection was developed for the determination of nivacortol (WIN 27914) in biological samples. The drug was isolated from human plasma by using a solid-phase extraction and eluted with ethanol. The solvent was evaporated and the residue dissolved in the chromatographic eluent. The sample was subjected to chromatography on a C8 silica column and eluted with a gradient of acetonitrile in 0.1 M sodium acetate buffer, pH 6.5. A single concentration of a structural analogue (WIN 31338) was used as internal standard for the quantitative determination of the analyte. The plasma concentrations were below that needed to suppress ACTH secretion by pituitary cells in culture and did not suppress plasma ACTH in Nelson's syndrome.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bmc.1130010404
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    Paper (German National Licenses)
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