ISSN:
0003-276X
Keywords:
Life and Medical Sciences
;
Cell & Developmental Biology
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Medicine
Notes:
High incidences of cleft lip and palate (CLP) Produced by maternal intraperitoneal administration of 75 mg/kg pehnytoin on gestational day 10 to A/J mice are associated with asevere size reduction in the lateral nasal process. Scanning and transmission EM analyses of this region demonstrate a marked change in the morphology of the mesenchymal cells underlying the surface epithelium in treated versus control day 11 (7-tail somite) embryos: long, branching cellular processes, which form a dense meshwork that appears to interact with the epithelial basement lamina in control embryos are undeveloped or absent in phenytoin-treated embryos. The ultrastructural morphology of these cell processes is described and their possible importance in normal development is discussed. Scanning EM observations of incomplete clefts of the lip which frequently result from phenytoin treatment indicate that Simonart's bands form from fusionof the lateral and medial nasal processes in association with a lack of fusion of the maxillary process with the medial nasal process.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/ar.1091950201
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