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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 21 (1982), S. 373-377 
    ISSN: 1432-1041
    Keywords: propranolol ; sotalol ; thyrotoxicosis ; bioavailability ; serum tri-iodothyronine ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The elimination and bioavailability of two beta-blocking agents, propranolol and sotalol, were studied in 10 thyrotoxic patients, both before and after treatment with iodine-131. Each subject received in random order propranolol 160 mg and sotalol 160mg as single oral doses both while hyperthyroid and after euthyroidism had been achieved. The pharmacokinetics of sotalol was not affected by hyperthyroidism, whereas serum propranolol concentrations were significantly lower during hyperthyroidism than in the euthyroid state. During hyperthyroidism, the bioavailability of propranolol was significantly reduced (p〈0.05) and its clearance was increased (p〈0.005), whereas there was no difference in its serum t1/2. This indicates that the bioavailability of propranolol in hyperthyroidism is reduced by a mechanism which may depend on increased first-pass metabolism in the liver, or on an increased distribution volume of the drug. Both propranolol and sotalol caused a slight decrease in serum tri-iodothyronine concentration. As the effects of beta-blocking agents on the symptoms of hyperthyroidism are correlated with the serum concentration of the drugs, sotalol, with its long half-life and unaltered elimination in hyperthyroidism, has certain advantages over propranolol in the treatment of thyrotoxicosis.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Steroid Biochemistry 36 (1990), S. 243-247 
    ISSN: 0022-4731
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Steroid Biochemistry 28 (1987), S. 95 
    ISSN: 0022-4731
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Thin Solid Films 96 (1982), S. 93-101 
    ISSN: 0040-6090
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Thin Solid Films 80 (1981), S. 55-61 
    ISSN: 0040-6090
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Vacuum 35 (1985), S. 58 
    ISSN: 0042-207X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1573-0956
    Keywords: Climate ; cloud-radiation interactions ; cirrus ; cloud modelling ; cloud microphysics ; field campaigns
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract The dominant role of clouds in modulating and interacting with radiative energy transports within the atmosphere, in providing precipitation, transporting water and influencing air-chemical processes is still not understood well enough to be accurately represented within atmospheric circulation and climate models over all regions of the globe. Also the extraction of real-world cloud properties from satellite measurements still contains uncertainties. Therefore, various projects have been developed within the Global Energy and Water Cycle Experiment (GEWEX), to achieve more accurate solutions for this problem by direct measurements within cloud fields and other complementary studies. They are based on the hypothesis, that most relevant properties of cloud fields can be parametrized on the basis of the prognostic field variables of atmospheric circulation models, and that the cloud microphysical properties can directly be related – with additional parameters on the particle shapes etc. – to the radiative transfer properties. One of these projects has been the European Cloud and Radiation Experiment (EUCREX) with its predecessor ICE (International Cirrus Experiment). The EUCREX and ICE provided a common platform for research groups from France, Germany, Sweden and the United Kingdom to concentrate their efforts primarily on high, cold cirrus. They showed, with data from satellites, that this cloud species enhances the atmospheric greenhouse-effect. Numerical mesoscale models were used in sensitivity studies on cloud developments. In-situ measurements of cloud properties were made during more than 30 aircraft missions, where also in-flight comparisons of various instruments were made to ensure the quality of data sets measured from different aircraft. The particle sampling probes, used for in-cloud measurements, showed a disagreement in total number density in all ranges between about 20–50%, while all other instruments agreed quite satisfactorily. A few measured holographic data provided information on typical ice-crystal shapes, which were used in numerical simulations of their absorption and scattering properties. Several new instruments for both in-situ and remote measurement, such as a polar nephelometer, a chopped pyrgeometer and an imaging multispectral polarimeter (POLDER) for cloud and radiation measurements were tested and improved. New algorithms were developed for cloud classifications in multispectral satellite images and also for simulations of the scattering of radiation by non-spherical particles. This paper primarily summarizes the EUCREX results obtained between 1989 and 1996, and provides examples of the many results which have been obtained so far. It is not a complete review of the world-wide state in this field, but it tries to place the EUCREX results into the world-wide development. Therefore many references are made to the results of other groups, which in turn influenced the work within EUCREX.
    Type of Medium: Electronic Resource
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