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  • 1
    Electronic Resource
    Electronic Resource
    The induction of the α-1-adrenoceptor signal transduction system on human melanocytes (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Experimental dermatology 5 (1996), S. 0 
    Details
    ISSN: 1600-0625
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract Human melanocytes established in MCDB-153 culture medium do not express α1-, β1-, β-2 adrenoceptors without extracellular stimulation. The addition of 50×10−9 M norepinephrine to the medium causes a time-dependent induction of α-1-adrenoceptors with 4.278 receptors/melanocyte after 24 h. Under the same experimental conditions, the dendricity of melanocytes as well as melanogenesis was unaffected over 60 h. Since keralinocytes hold the full capacity for catecholamine biosynthesis but melanocytes lack this system, the secretion of catecholamines from keratinocytes appears to be of critical importance to the α-1-adrenoceptor in melanocytes, underlining the symbiosis of both cells in the epidermal unit.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0625.1996.tb00088.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Defective calcium transport in vitiliginous melanocytes (1995)
    Springer
    Archives of dermatological research 288 (1995), S. 11-13 
    Details
    ISSN: 1432-069X
    Keywords: Key words Calcium transport ; Melanocytes ; Vitiligo ; 6-Biopterin/6BH4 ; Redox status
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Melanocytes were successfully established from involved and uninvolved skin of a patient with acute acrofacial vitiligo. Cells from involved epidermis showed a fivefold decrease in the rate of radiolabelled 45 Ca uptake compared with uninvolved and control cells. These results are similar to previous findings in keratinocytes from involved skin in patients with vitiligo. Since 6-biopterin is cytotoxic to melanocytes and calcium controls the redox status of the 6-biopterin /(6 R )5, 6, 7, 8-tetrahydrobiopterin equilibrium via the thioredoxin reductase/thioredoxin system, these results underline the importance of this electron transfer system for both melanocyte function and survival.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004030050015
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Altered catecholamine synthesis and degradation in the epidermis of patients with atopic eczema (1997)
    Springer
    Archives of dermatological research 289 (1997), S. 663-666 
    Details
    ISSN: 1432-069X
    Keywords: Key words Catecholamines ; MAO-A ; Atopic eczema ; Phenylethanolamine-N-methyl-transferase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Patients with atopic eczema have significantly higher norepinephrine levels in plasma than healthy controls. In addition, significantly higher levels of the essential cofactor (6R)-l-erythro-5,6,7,8-tetrahydrobiopterin (6BH4) were found in this patient group. Cell extracts from epidermal suction blister roofs revealed only half the normal activity of phenylethanolamine-N-methyl transferase (PNMT) together with a threefold induction of the norepinephrine-degrading enzyme monoamine oxidase A (MAO-A). Taken together, these results support earlier observations of a defective catecholamine/adrenoceptor signal in patients with atopic eczema.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004030050258
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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