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  • 1
    Electronic Resource
    Electronic Resource
    Phytohaemagglutinin-Induced Leukocyte Migration Inhibition and Phytohaemagglutinin Skin Test for Screening the Cell-Mediated Immune Response in Children (1980)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 35 (1980), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Phytohaemagglutinin-induced leukocyte migration inhibition was studied in 72 children and compared with phytohaemagglutinin skin testing. The methods were used for screening the cell-mediated immune espouse. The in vitro method, which requires only 10- 15% of the number of migrating cells as compared with other migration techniques, proved to be more sensitive, but gave some false-positive results when compared with other immunological parameters. Nevertheless, application of the microdroplet leukocyte migration is advantageous, used either simultaneously with the skin test, or as a single screening method in prematures, mature newborns and young infants, where application and/or evaluation of the skin tests is difficult.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.1980.tb01805.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    THE INHIBITORY EFFECT OF LEUKAEMIA ASSOCIATED ANTIGEN AND LEUKAEMIC SERUM ON THE LEUKOCYTE MIGRATION OF CHILDREN WITH ACUTE LEUKAEMIA IN REMISSION (1974)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 29 (1974), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.1974.tb01656.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Leukocyte Migration Inhibition with Epstein-Barr Virus Negative and Positive Cell Extracts (1980)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 35 (1980), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Leukocyte migration inhibition of seronegative and seropositive healthy children and that of patients with infectious mononucleosis was studied in the presence of EBV-negative and -positive cell extracts. Seronegative children showed no alteration of the leukocyte migration in the presence of the extracts. EBV-positive cell extracts caused significant migration inhibition in the group of seropositive healthy children and of IM patients. The effect was specific, since the EBV-negative cell extract had no inhibitory effect. In the acute phase of infectious mononucleosis a depressed response was observed, while after recovery the same migration inhibition could be detected. The possible cause of the depressed cell-mediated immune response in the acute phase of the disease is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.1980.tb01723.x
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Interferon suppresses antigen- and mitogen-induced leukocyte migration inhibition (1980)
    [s.l.] : Nature Publishing Group
    Nature 288 (1980), S. 594-596 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The agarose microdroplet technique14 was used in two systems: migration inhibition induced by phytohaemagglutinin (PHA) and LMI of leukocytes from Epstein-Barr virus (EBV)-seropositive donors after exposure to EBV antigens. Washed buffy coat cells (20xl06) were mixed with 135 ? nutrient agarose ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/288594a0
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Nitric oxide and ATP co-mediate the NANC relaxant response in the guinea-pig taenia caeci (1998)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 358 (1998), S. 496-499 
    Details
    ISSN: 1432-1912
    Keywords: Key words Taenia caeci (guinea-pig) ; Nitric oxide ; NG-nitro-l-arginine ; P2 purinoceptors ; PPADS
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of the nitric oxide synthase inhibitor N G-nitro-l-arginine (l-NOARG; 100 µM) and the P2 purinoceptor antagonist pyridoxalphosphate-6-azophenyl-2’,4’-disulfonic acid (PPADS; 50 µM) was investigated on the non-adrenergic, non-cholinergic (NANC) relaxant response of the guinea-pig isolated taenia caeci to electrical field stimulation at 1 or 10 Hz, under isotonic recording conditions. Either drug alone caused an about 50% inhibition, while combining the two drugs nearly abolished the response at both frequencies. The inhibitory effect of l-NOARG (100 µM) was partly reversed by l-arginine (30 mM). PPADS, but not l-NOARG, inhibited the relaxant effect of exogenous ATP, but not that of the nitric oxide donor sodium nitroprusside. It is concluded that both nitric oxide and ATP are involved in the mediation of NANC relaxation in the taenia caeci, in an apparently additive manner.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00005283
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  • 6
    Electronic Resource
    Electronic Resource
    Progressive vaccinia: Immunological aspects and transfer factor therapy (1978)
    Springer
    Infection 6 (1978), S. 149-153 
    Details
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die progressive Vaccina ist eine seltene und schwerwiegende Komplikation der Pocken-Schutzimpfung. Als zugrunde liegende Störung findet man im allgemeinen einen herabgesetzten Immunmechanismus. Von angemessener Immunkorrektur kann daher therapeutische Wirksamkeit erwartet werden. In einem Fall wurde während des Verlaufs der Krankheit die humorale und zytergische Immunität mehrfach untersucht. Die Ergebnisse wiesen auf teilweise Defizienz der zytergischen Immunität hin. Durch Anwendung von menschlichem Antivaccina-Immunglobulin und N-Methylisatin-β-thiosemicarbazon ließ sich keine therapeutische Wirkung erzielen. Eine Behandlung mit Übertragungsfaktor wurde ebenfalls versucht. Die Therapie mit einem unspezifischen Übertragungsfaktor-Präparat hatte vorübergehende klinische Besserung zur Folge. Ein während des letzten Lebensmonats verabfolgtes spezifisches Übertragungsfaktor-Präparat zeitigte jedoch keine therapeutische Wirkung. Der Patient verstarb am 145. Tag nach der Impfung. Die Autopsiebefunde wiesen auf kombinierte Immundefizienz hin.
    Notes: Summary Progressive vaccinia is a rare and serious complication of smallpox vaccination. Depressed immune function can generally be found as an underlying disorder; thus adequate immuno-correction may be expected to be therapeutically effective. Humoral and cell-mediated immunity was repeatedly examined in one case throughout the course of the disease. Results indicated partial deficiency of cell-mediated immunity. No therapeutic effect was achieved by using human antivaccinia immunoglobulin and N-methylisatin β-thiosemicarbazone. Transfer factor therapy was also attempted. Treatment with a non-specific transfer factor preparation was followed by a transitory clinical improvement. A specific transfer factor preparation given during the last month of life, however, had no therapeutic effect. The patient died on the 145th day after vaccination. Autopsy findings pointed to combined immune deficiency.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01641902
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    Paper (German National Licenses)
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