ISSN:
0170-2041
Keywords:
Eburnanes
;
Alkaloids
;
Cardiovascular effects
;
Indolo[2,3-a]quinolizines
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The synthesis of all the possible isomers of the eburnameninevincamine type alkaloids 1b, 2a, 3a and derivatives 4, 8, 9, 10 is described. Structures were determined by 1H- and 13C-NMR spectroscopy including special techniques such as DR, DEPT, DNOE, and 2D-HSC. In contrast to the known cerebrovascular effects of cis-(3S,16S) compounds, trans-(3S,16R) derivatives show a significant peripheral vasodilator effect.
Additional Material:
5 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jlac.199319930140
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