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  • 1
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Forty-seven patients with locally advanced cervical cancer at high risk of relapse received three cycles of chemotherapy with PVB (cisplatin, vinblastine and bleomycin) before definitive local treatment with either radical surgery or radiotherapy. Thirty-one of the 47 patients (66%) responded to initial chemotherapy, and 11 of them have relapsed compared with 13 of the 16 non-responders. Median time to recurrence was 31 weeks for PVB non-responders but has not yet been reached for PVB responders. After a median follow-up of 128 weeks, 14 of the 31 responders (45 %) are alive and disease free compared with 3 of the 16 non-responders (19%). There was a positive correlation between response to chemotherapy and subsequent response to radiotherapy. PVB was in general well tolerated although one death is probably attributable to chemotherapy. A randomized study comparing radiotherapy alone with initial PVB chemotherapy followed by radiotherapy is in progress.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 255 (1975), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 308 (1978), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1569-8041
    Keywords: information ; involvement ; preferences ; stability ; support
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: While the importance of providing individualised communication to cancer patients is now well recognised, little is known about the stability and validity of patients' expressed preferences for information and involvement in decision-making. This study explored the stability and possible predictors of such preferences over time. Patients and methods: Cancer patients seeing two Medical Oncologists in an out-patient clinic at an Australian teaching hospital completed a questionnaire battery before and directly after one consultation, and before their next consultation. Eighty consecutive patients with heterogeneous cancers participated in the study. Preferences for general and specific information, involvement and support were elicited at each assessment. Locus of control and patient familiarity with the clinic were measured before the first consultation. Patient satisfaction with the consultation was assessed directly after the consultation. Demographic and disease data were recorded for each patient. Results: General preferences for information and involvement were relatively stable, at least in the short term; however there was considerable variability in preferences for specific topics of information. Patients whose condition had recently worsened were more likely to want progressively less involvement in decision-making. Gender, the doctor seen and religion were also predictive of patient preferences. Conclusions: Situational factors, such as change in disease status, may alter a patient's preferences for information and involvement. If we wish to match the provision of information and support to the expressed needs of patients, we must ask patients at each consultation what those needs are.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Annals of oncology 10 (1999), S. 39-46 
    ISSN: 1569-8041
    Keywords: doctor–patient relations ; informed consent ; patient denial ; patient understanding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Aim: We aimed to document the prevalence of misunderstanding in cancer patients and investigate whether patient denial is related to misunderstanding. Patients and methods: Two hundred forty-four adult cancer outpatients receiving treatment completed a survey assessing levels of understanding and denial. Doctors provided the facts against which patient responses were compared. Multiple logistic regression analyses determined the predictors of misunderstanding. Results: Most patients understood the extent of their disease (71%, 95% CI: 65%–77%) and goal of treatment (60%, 95% CI: 54%–67%). Few correctly estimated the likelihood of treatment achieving cure (18%, 95% CI: 13%–23%), prolongation of life (13%, 95% CI: 8%–17%) and palliation (18%, 95% CI: 10%–27%). Patient denial predicted misunderstanding of the probability that treatment would cure disease when controlling for other patient and disease variables (OR = 2.20, 95% CI: 0.99–4.88, P = 0.05). Patient ratings of the clarity of information received were also predictive of patient understanding. Conclusions:Patient denial appears to produce misunderstanding, however, doctors' ability to communicate effectively is also implicated. The challenge that oncologists face is how to communicate information in a manner which is both responsive to patients' emotional status and sufficiently informative to allow informed decision-making to take place.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Supportive care in cancer 1 (1993), S. 19-25 
    ISSN: 1433-7339
    Keywords: Cancer ; Hypercalcaemia ; Humoral hypercalcaemia ; Management
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Hypercalcaemia is a well-recognised complication in partients with several types of cancer. Since determination of the serum calcium has become routine particularly in hospital patients, the identification of hypercalcaemia associated with cancer has increased. Cancer is the most common cause of hypercalcaemia arising in hospitalised patients, and overall approximately onethird of all patients presenting with hypercalcaemia have an underlying cancer. In Western countries, the common causes of hypercalcaemia are cancers of the lung and breast. The median survival of patients with hypercalcaemia and cancer is only 5 weeks, indicating that in many patients treating hypercalcaemia may not achieve prolonged survical, even if symptoms are palliated. The clinical presentations of hypercalcaemia are well known, encompassing gastrointestinal, neurological, cardiovascular and renal symptoms. Management approaches have evolved over the past few years from hydration and use of drugs that promote calcium excretion to new treatments that inhibit bone resorption.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 253 (1975), S. 198-200 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] LI210 Leukaemic cells (105) were injected intraperiton-eally into BDFi male mice, and MTX, CF, TdR, or allopurinol injected intraperitoneally at least 24 h after the inoculation of leukaemic cells. The animals were weighed weekly and observed for toxicity and survival. Since animals dying of drug ...
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Supportive care in cancer 5 (1997), S. 85-89 
    ISSN: 1433-7339
    Keywords: Information needs ; Information technology ; Decision making
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Advances in information technology, and changing patient expectation in regard to provision of information and participation in clinical decisions are already influencing the cancer consultation. In future, the oncologist's role will evolve further, and the cancer consultation beyond the year 2000 will be an opportunity for information relating to the particular patient's circumstances to be presented according to the patient's wishes. Patients' desired input into clinical decisions will be respected, and consultation audiotapes will be a widely used aid for patients after the consultation.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Supportive care in cancer 5 (1997), S. 85-89 
    ISSN: 1433-7339
    Keywords: Key words Information needs ; Information technology ; Decision making
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Advances in information technology, and changing patient expectation in regard to provision of information and participation in clinical decisions are already influencing the cancer consultation. In future, the oncologist's role will evolve further, and the cancer consultation beyond the year 2000 will be an opportunity for information relating to the particular patient's circumstances to be presented according to the patient's wishes. Patients' desired input into clinical decisions will be respected, and consultation audiotapes will be a widely used aid for patients after the consultation.
    Type of Medium: Electronic Resource
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