Digitale Medien
Oxford, UK
:
Blackwell Publishing Ltd
Scandinavian journal of immunology
22 (1985), S. 0
ISSN:
1365-3083
Quelle:
Blackwell Publishing Journal Backfiles 1879-2005
Thema:
Medizin
Notizen:
The effects of influenza virus A (H3N2) on several functions of human polymorphonuclear leukocytes (PMN) were examined. Incubation of PMN with virus induced chemiluminescence, aggregation, and degranulation of the leukocytes. The amount of chemiluminescence generated increased from 1 × 106 to 6 × 106 cpm when 2.5 × 106 to 2 × 107 virus particles were added to 2.5 × 106 PMN. Maximal aggregation occurred within 2 min and the response depended on the amount of virus added to the PMN. Release of acid phosphatase by virus-treated PMN was 62±12% within 1 h compared with 7 + 7% by control PMN (P〈0.005). Incubation of PMN with influenza virus resulted in a diminished phagocytic activity of the phagocytes. PMN from a patient with chronic granulomatous disease were similarly affected. It was thus concluded that the observed defect in phagocytic activity was not due to the reactive oxygen species generated hy the PMN during incubation with virus.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1111/j.1365-3083.1985.tb01935.x
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