ISSN:
1573-7330
Keywords:
Oocyte maturation
;
follicular fluid
;
inhibin-B
;
inhibin-A
;
assisted reproductive technology
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Purpose: The aim was to investigate the relationship ofintrafollicular inhibin dimers A and B with human oocytemorphology and subsequent embryo potential. Methods: Sixty-eight oocytes were isolated from 31 womenundertaking intracytoplasmic sperm injection (ICSI).Estradiol, progesterone, testosterone, luteinizing hormone (LH),follicle-stimulating hormone (FSH), prolactin, sexhormone-binding globulin, inhibin-A and inhibin-B was assayed incorresponding follicular fluid. Results: The mean (±SD) concentration for inhibin-A was9.7 ± 9.8 ng/ml (range, 1.1–60.0 ng/ml) and for inhibin-Bwas 269.4 ± 185.2 ng/ml (range, 33.1–811.0 ng/ml). In acorrelation matrix there were no marked relationships (r 〈0.556) between inhibin and steroid or gonadotropin concentrations. Similarly, when inhibin concentrations were dividedaccording to whether the oocytes had mature or immaturecumulous complexes, were viable or necrotic, were meiotically immature or mature, became fertilized or not, or haddifferent embryo gradings after cleavage, no statisticallysignificant difference could be seen between groupings. Conclusions: Because the range of values was large and thedata often skewed, neither inhibin dimer has discriminatorypower to reflect the potential of the oocyte.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1009461117779
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