ISSN:
1365-2036
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Background : Proton pump inhibitors control gastric acidity better during the day than at night, when nocturnal acid breakthrough can occur. Tenatoprazole is a novel proton pump inhibitor with a seven-fold longer plasma half-life.Aim : To compare the effects of tenatoprazole 20 mg (T20), tenatoprazole 40 mg (T40) and esomeprazole 40 mg (E40) on intragastric acidity in healthy volunteers.Methods : This randomized, three-period, cross-over study enrolled 18 Helicobacter pylori-negative volunteers, who received E40, T20 and T40 once daily for 7 days with a 14-day washout between periods. Twenty-four-hour gastric pH monitoring was performed on day 7. Serum gastrin was assessed on day 8.Results : T40 induced a more potent acid inhibition than T20 (24-h median pH: 4.6 vs. 4.0, P 〈 0.01; daytime: 4.5 vs. 3.9, P 〈 0.01; night-time: 4.7 vs. 4.1, P 〈 0.05). T40 was more potent than E40 (24-h median pH: 4.6 vs. 4.2, P 〈 0.05; night-time: 4.7 vs. 3.6, P 〈 0.01); the pH 〉 4 holding time was higher during the night for T40 than for E40: 64.3% vs. 46.8%, P 〈 0.01; the nocturnal acid breakthrough duration was significantly shorter for T40 than for E40. No significant gastrin increase was observed and all drugs were well tolerated.Conclusion : T40 is significantly more potent than T20 and E40 during the night. The therapeutic relevance of this pharmacological advantage deserves further study.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1365-2036.2004.01893.x
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