ISSN:
0170-2041
Keywords:
Asymmetric reduction
;
Baker's yeast
;
Yeast
;
Saccharomyces cerevisiae
;
Enzymes
;
trans-1-Decalone derivatives
;
trans-1,8-Decalindione derivatives
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Reduction of 9-methyl-trans-decalin-1,8-dione (1) with baker's yeast affords (8S,9R,10R)-8-hydroxy-9-methyl-trans-1-decalone (8) as the major product in 47% yield. Its (8S,9S,10S)-isomer (9, 14% yield) and (1S,8S)-9-methyl-trans-decalin-1,8-diol (10, 7% yield) are obtained as minor products. Baker's yeast cannot reduce 9-methyl-cis-decalin-1,8-dione (2).
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jlac.199319930115
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