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  • 1
    Electronic Resource
    Electronic Resource
    Bioavailability of 50- and 75-mg oral etoposide in lung cancer patients (1996)
    Springer
    Cancer chemotherapy and pharmacology 37 (1996), S. 327-331 
    Details
    ISSN: 1432-0843
    Keywords: Key words Etoposide ; Bioavailability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  This study was designed to determine the bioavailability of etoposide capsules administered orally at doses of 50 and 75 mg. Patients with inoperable or relapsed lung cancer, who had an Eastern Cooperative Oncology Group (ECOG) performance status of 0–2 and adequate organ function, were eligible. A group of 17 patients were evaluable, all of whom were 75 years old or less, with an ECOG performance status of 0 or 1. The bioavailability of oral etoposide was determined by measuring the area under the etoposide plasma concentration versus time curve (AUC) on days 1, 10 and 21 during a once-daily regimen of oral administration for 21 consecutive days and comparing the value with the AUC achieved following intravenous administration 1 or 2 weeks after the last oral dose. The bioavailability of 50, 75 and 100 mg oral etoposide was determined in six, nine and two patients, respectively. The mean etoposide bioavailabilities (±SD) of the 50-mg and 75-mg doses were 47±11% and 59±18%, respectively, and of the 100-mg dose in two patients were 51% and 33%, respectively. There was no statistically significant difference in bioavailability between the 50-mg and 75-mg doses. The bioavailability of low-dose oral etoposide was the same as that reported in previous higher dose oral etoposide bioavailability studies and that shown on the package insert supplied by the manufacturer. Improved bioavailability of low-dose oral etoposide was therefore not observed in a population of Japanese patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002800050392
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Preclinical detection in Japanese families with myotonic dystrophy using polymorphic DNA markers (1989)
    Springer
    Journal of human genetics 34 (1989), S. 189-194 
    Details
    ISSN: 1435-232X
    Keywords: myotonic dystrophy ; DNA diagnosis ; apolipoprotein CII (APOC2) ; D19S19 ; restriction fragment length polymorphisms (RFLPs)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Myotonic dystrophy (DM) is a genetic disease inherited by an autosomal dominant trait and characterized by multi-organ disorders. Although its biochemical basis has been unknown, the DM locus is closely linked to D19S19 and APOC2 on the long arm of chromosome 19 both in Japanese and Caucasian populations. Linkage studies of Japanese DM families using these polymorphic DNA markers detected two asymptomatic gene carriers in two unrelated families.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01900720
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Characteristics of dynamic mutation in Japanese myotonic dystrophy (1994)
    Springer
    Journal of human genetics 39 (1994), S. 327-335 
    Details
    ISSN: 1435-232X
    Keywords: myotonic dystrophy ; unstable CTG repeat sequence ; anticipation ; dynamic mutation ; contraction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary To study the characteristics, if any, of unstable CTG repeat sequence in Japanese myotonic dystrophy (DM), we analyzed DNA from 351 at risk individuals (including affected and non-affected carriers and their descendants) from 105 families in Japan. A total of 93 DM families (196 affected and 116 unaffected individuals), including 84 DM parentchild pairs (44 father-child and 40 mother-child pairs), were examined, many of which had been previously tested by linkage analysis. We detected unstable CTG repeat mutations between 0.15 kb and 8.7 kb in size. The size of the mutation correlated with the age of onset of symptoms. There was a significant difference in DM allele size among the four groups (congenital, juvenile onset, classical, and minimal). Congenital DM had on average the largest repeat sizes. Comparison of parent-child pairs showed that most offspring had a larger repeat size than their parents, with only 2 of 84 showing a definite decrease in repeat size. The correlation coefficients for maternal and paternal transmission were 0.41 and 0.15, respectively. The parental age (maternal and paternal) did not correlate with intergenerational change of repeat. These observations are similar to those reported in Caucasians.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01874051
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    Paper (German National Licenses)
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