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  • 1
    Electronic Resource
    Electronic Resource
    Development of pollen-induced allergic rhinitis with early and late phase nasal blockage in guinea pigs (1998)
    Springer
    Inflammation research 47 (1998), S. 369-374 
    Details
    ISSN: 1420-908X
    Keywords: Key words: Allergic rhinitis — Nasal blockage — Sneeze — Pollen — Airway resistance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Objective and Design: Development of nasal blockage and sneezing during repeated inhalation challenges with Japanese cedar pollens was evaluated in guinea pigs.¶Subjects: Male Hartley guinea pigs.¶Treatment: Guinea pigs were sensitized by intranasal instillation of cedar pollen extracts + Al(OH)3 2 times a day for 7 days. The animal was then forced to inhale the pollens for challenge, which was restrictively trapped in the upper airways, once a week.¶Methods: Change of specific airway resistance (sRaw), sneezing frequency, and titers of anaphylactic antibodies in the serum were measured after each of the 30 challenges.¶Results: At the first challenge, no obvious increase in sRaw was observed. However, the second and third challenges to the animals caused modest biphasic elevations of sRaw, with peaks at the first and the fourth to sixth hour. At the fourth to tenth challenges, marked elevations of sRaw were observed. However, with repetition of the inhalation challenge, the early and the late responses became almost indistinguishable because of partial overlapping as the responses expanded. All guinea pigs sneezed immediately after each pollen inhalation challenge. Apparent increases of both circulating γ1 and IgE antibodies were seen after the seventh challenge.¶Conclusions: These results indicate that the experimental allergic rhinitis established in the present study can be a valuable model for analyzing the pathogenesis of the disease and developing new therapeutic drugs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000110050346
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  • 2
    Electronic Resource
    Electronic Resource
    Fatty acid effects on calcium influx and efflux in sarcoplasmic reticulum vesicles from rabbit skeletal muscle
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Biomembranes 687 (1982), S. 17-26 
    Details
    ISSN: 0005-2736
    Keywords: (Rabbit skeletal muscle) ; Ca^2^+ transport ; Fatty acid inhibition ; Oleic acid ; Stearic acid
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0005-2736(82)90165-1
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  • 3
    Electronic Resource
    Electronic Resource
    2-D reflectivity method and synthetic seismograms for irregularly layered structures—II. Invariant embedding approach (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Geophysical journal international 105 (1991), S. 0 
    Details
    ISSN: 1365-246X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: Laterally varying interfaces cause coupling between wavenumbers so that seismograms in two-dimensionally layered media can be synthesized by means of ‘supermatrices’, which include the coupled contributions of all the wavenumbers. We introduce reflection and transmission ‘supermatrices’ in order to eliminate numerical problems arising from loss of precision for evanescent waves in the seismogram synthesis. An interface is assumed to be such that the reflected and transmitted wavefields; on its two sides can be represented as purely upgoing and downgoing waves, i.e. the Rayleigh ansatz is imposed. The computational demands of this method can be kept to a minimum by exploiting propagation invariants in the coupled wavenumber domain.The superior performance of this ‘invariant embedding’ approach when compared to propagator or finite difference schemes is illustrated by application to the response of sedimentary basins to excitation by an incident plane wave or a line force. The results are in good general agreement with the other methods, but show greater numerical stability and computational efficiency. In the case of a single interface the ‘invariant embedding’ procedure for P-SV-waves takes 45 per cent less computation time and 29 per cent less memory than the propagator method of Koketsu (1987a, b). The gains are reduced in a multilayer case because of the level of computation required to calculate the addition rules for the large reflection and transmission supermatrices.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-246X.1991.tb03448.x
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  • 4
    Electronic Resource
    Electronic Resource
    Congenital malignant melanoma: a case report (2004)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 151 (2004), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Congenital malignant melanoma (MM) is an uncommon condition that is defined as MM recognized at birth. Its incidence is difficult to determine because of the small number of reported cases and because of problems associated with diagnosis. Generally, Spitz naevus and melanoma have many clinical and histopathological similarities, so it is difficult to differentiate between the two. We describe a rare case of congenital MM in which differential diagnosis from Spitz naevus was problematic. In addition, we review the literature and comment on the prognostic differences among the three types of congenital and infantile MM.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.2004.06157.x
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  • 5
    Electronic Resource
    Electronic Resource
    Follicular lupus erythematosus: a new cutaneous manifestation of systemic lupus erythematosus (2002)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 147 (2002), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary We report the clinical, histopathological and immunological features of follicular erythema and petechiae in a 30-year-old Japanese woman with systemic lupus erythematosus (SLE). Histology showed this eruption to constitute a cutaneous manifestation of SLE. To our knowledge, this is the first reported case of follicular erythema and petechiae in association with SLE. Accordingly, we propose that this rare eruption be termed ‘follicular lupus erythematosus’.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2002.04728.x
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  • 6
    Electronic Resource
    Electronic Resource
    Spatial and temporal expression of basic fibroblast growth factor protein during wound healing of rat skin (2000)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 143 (2000), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Basic fibroblast growth factor (bFGF) stimulates the mitogenesis of various cells and plays a key part in wound healing. Objectives To determine the spatial and temporal expression of bFGF protein during wound healing after burning of rat skin. Methods Immunohistochemical methods were used. Results The immunostaining for bFGF in the normal epidermis was faint and sporadic in the basal cell layer. However, significant staining for bFGF was found in four locations: regenerated epidermis, a band-like zone near the regenerated epidermis, renewed capillaries, and cells infiltrating into the granulation tissue at the inflammatory to proliferative stages after the burn. The intensity of immunostaining of regenerated epidermis, the band-like zone and renewed capillaries was maximal during the proliferative stage and decreased to normal levels or disappeared simultaneously with wound closure. Immunopositive macrophage-like cell numbers in the granulation tissue increased during the proliferative stage and promptly decreased after wound closure, but such cells were only poorly visible in the scar tissue until 42 days postburn. Conclusions bFGF may affect the proliferation, differentiation and migration of regenerated keratinocytes and the recruitment of inflammatory cells, as well as neovascularization in granulation tissue during wound healing. Macrophages may play a pivotal role in cutaneous wound repair by producing bFGF not only during the inflammatory or proliferative stages but also during the remodelling stage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.2000.03824.x
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  • 7
    Electronic Resource
    Electronic Resource
    Apoptosis and p53 protein expression increase in the process of burn wound healing in guinea-pig skin (1999)
    Oxford BSL : Blackwell Science Ltd
    British journal of dermatology 140 (1999), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Apoptosis and the expression of p53 protein, an apoptosis-related protein, in the process of healing of a full-thickness burn wound in guinea-pig skin were studied with the terminal deoxynucleotide transferase nick-end labelling method, electron microscopy, and immunohistochemistry, respectively. Apoptosis was detected in the peripheral zone of heat-injured skin from 12 h until day 10 after the burn, with the peak occurring on day 2. The peripheral zone of heat-injured skin showed p53 protein from 12 h through day 2, with the peak occurring on day 2. Apoptosis was also detected in tissues regenerated for covering skin defects. The peak of apoptosis in the regenerated epidermis occurred at days 7–10, when the epidermis was most acanthotic. p53 protein reactivity was also detected in the acanthotic regenerated epidermis, with a peak on day 7. The peak of apoptosis in the granulation and scar tissue took place from day 10 to 14, when the granulation tissue started diminishing, but p53 protein reactivity was not detected there. These findings suggest that apoptosis plays an important part in the elimination of dying and/or dead cells resulting from heat stress, the terminal differentiation of the regenerated epidermis, and the decrease in cellularity during remodelling. The apoptotic process during remodelling may be mediated by some p53-independent pathway.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.1999.02811.x
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  • 8
    Electronic Resource
    Electronic Resource
    Verruciform xanthoma in association with a vulval fibroepithelial polyp (1997)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 137 (1997), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary We report the clinical, light microscopic, immunohistochemical and ultrastructural features of a verruciform xanthoma that developed in association with a vulval fibroepithelial polyp. To our knowledge, this is the first time that this association has been reported. Immunohistochemical findings confirmed that the xanthoma cells were of a monocyte/macrophage lineage. In addition to typical histological characteristics, prominent vascular ectasias were detected in the deep dermis at the periphery of this lesion. The ectasias may play a part in pathogenesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.1997.19602036.x
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  • 9
    Electronic Resource
    Electronic Resource
    Widespread cutaneous oxalosis in a patient with primary hyperoxaluria (2003)
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 149 (2003), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.2003.05555.x
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  • 10
    Electronic Resource
    Electronic Resource
    Recurrent malignant proliferating trichilemmal tumour: local management with ethanol injection (1998)
    Oxford BSL : Blackwell Science Ltd
    British journal of dermatology 139 (1998), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We report a 59-year-old woman who exhibited a recurrent malignant proliferating trichilemmal tumour on the scalp for 15 years. The tumour was recalcitrant to conventional treatments such as chemotherapy, radiation or hyperthermia and we performed intratumoral ethanol injection as an alternative means of reducing tumour mass and obtaining haemostasis. Biopsy specimens obtained after the ethanol injection revealed oedema, haemorrhage in the dermis and degeneration of the tumour cells, showing vacuolization with pyknotic nuclei. For cases of recurrent skin tumours and for patients in poor clinical condition, intratumoral ethanol injection is likely to be a therapeutic alternative to surgery or other conventional treatments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2133.1998.02477.x
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