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  • 1
    Electronic Resource
    Electronic Resource
    Multicentric liposarcoma (2004)
    Melbourne, Australia : Blackwell Science Pty
    International journal of urology 11 (2004), S. 0 
    Details
    ISSN: 1442-2042
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract  A 72-year-old man complaining of upper abdominal discomfort was diagnosed as having retroperitoneal liposarcoma by means of diagnostic imaging. He then underwent an operation. One mass existed on the curvatura ventriculi major, extending to the hilum splenicum and pressing back the pancreal head and body. There was another mass to the left of the first, situated on the ventral side of the left kidney. Also, another mass was intramurally found adjacent to the curvatura ventriculi major. Histologically, the mass on the curvatura ventriculi major ranged from the peritoneal cavity to the retroperitoneum Its intraperitoneal portion was classified as a differentiated lipoma-like type and the retroperitoneal mass was of mucous type. The mass on the left kidney was of a differentiated fibrosing type. The intramural mass in the gastric curvature was found to be a differentiated lipoma-like type. The patient has been under observation for 12 months and has shown no recurrence.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1442-2042.2004.00958.x
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  • 2
    Electronic Resource
    Electronic Resource
    Histopathologic analysis of angiogenic factors in localized renal cell carcinoma: The influence of neoadjuvant treatment (2001)
    Melbourne, Australia : Blackwell Science Pty
    International journal of urology 8 (2001), S. 0 
    Details
    ISSN: 1442-2042
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: This study was conducted in order to clarify whether histopathologic analysis of factor thymidine phosphorylase (TP) and Factor VIII could be a useful predictor of postoperative recurrence in localized renal cell carcinoma. Therefore, the relationship between tumor infiltrated lymphocytes (TIL) and both TP and Factor VIII was studied.〈section xml:id="abs1-3"〉〈title type="main"〉Method:Of the 71 patients who underwent surgery, 54 patients had no neoadjuvant therapy (group 1), 10 patients were preoperatively administered IFN-γ (group 2), and the remaining seven patients preoperatively received IFN-γ and transarterial embolization (group 3). Both TP and Factor VIII immunostaining were performed on formalin-fixed, paraffin-embedded archival tissue from 71 renal cell carcinoma specimens, while TIL immunostaining was performed on frozen sections. Positive immunostaining was quantitatively scored by a computer-assisted digital image analysis. For TIL, positive results were semiquantitatively scored.Results:A significant difference in the recurrence-free rate was recognized for Groups 1, 2 and 3 (P 〈 0.05). Therefore, the median TP-positive rate (PR), VIII-PR, number of microvessels and positive mean vascular area levels were investigated, between the recurrence cases (n = 6) and the recurrence-free cases (n = 11). Only the TP-PR levels showed a significant difference among them (P = 0.044). In regards to the neoadjuvant cases, a significant correlation was observed between both VIII-PR and CD4 (r = 0.815) as well as between VIII-PR and CD11b (r = 0.756).Conclusion:There was no clear evidence that the neoadjuvant treatment would increase the recurrence-free survival in patients with localized renal cell carcinoma. TP-PR might be a predictor of postoperative recurrence in patients with localized renal cell carcinoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1442-2042.2001.00299.x
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  • 3
    Electronic Resource
    Electronic Resource
    Cytoreductive surgery with liver-involved renal cell carcinoma (2000)
    Melbourne, Australia : Blackwell Science Pty
    International journal of urology 7 (2000), S. 0 
    Details
    ISSN: 1442-2042
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The purpose of this study was to demonstrate the benefits of cytoreductive surgery for renal cell carcinomas that also involve the liver. Between 1994 and 1997, four patients with renal cell carcinoma with liver involvement were surgically treated with nephrectomy and hepatectomy. Two of them underwent a simultaneous hepatectomy and nephrectomy (group 1), and the remaining two patients underwent a hepatectomy after a nephrectomy and had a diagnosis of postoperative recurrence (group 2). Two patients, one from each group, died of multiple bone metastasis and lung metastasis 30 months and 12 months after the hepatectomy; the second patient from group 1 died 40 months after the first operation due to gastrointestinal hemorrhaging. The second patient from group 2 displayed no evidence of recurrence 18 months after the second surgical procedure. The survival rates for these patients were 66% and 33% at 1 and 3 years, respectively. Autopsy studies revealed that one patient from group 2 had a local recurrence in the liver while the other two patients from group 1 did not. Our results suggested that a progressive approach may therefore be useful for patients demonstrating renal cell carcinoma where there is liver involvement.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1442-2042.2000.00209.x
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  • 4
    Electronic Resource
    Electronic Resource
    Histopathological analysis of angiogenic factors in renal cell carcinoma (2003)
    Melbourne, Australia : Blackwell Science Pty
    International journal of urology 10 (2003), S. 0 
    Details
    ISSN: 1442-2042
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aim: The present study was carried out to clarify whether a histopathological analysis of vascular endothelial growth factor (VEGF), transforming growth factor-β1 (TGF-β1) and matrix metalloproteinase 2 (MMP-2) can help predict the outcome of renal cell carcinoma (RCC). We examined the expression of VEGF, TGF-β1 and MMP-2 in a large series of RCC with a long follow-up, based on histopathological factors and survival.Methods: Immunostaining for VEGF, TGF-β1 and MMP-2 was performed on formalin-fixed, paraffin-embedded tissue sections from 84 patients with RCC who underwent nephrectomy at our institution between 1985 to 2000. The microvessel density (MVD) of tumor tissue was measured after it immunohistochemically stained with CD105 (Endoglin) monoclonal antibody.Results: A significant association was observed in the expression of VEGF and TGF-β1 regarding the stage (P 〈 0.01, P 〈 0.01), nuclear grade (P 〈 0.01, P 〈 0.01) and MVD (P 〈 0.001, P 〈 0.001), respectively. However, no correlation was found among the results of MMP-2, nuclear grade and MVD. A multivariate analysis demonstrated both the nuclear grade and MVD to be independent prognostic factors.Conclusion: Our results suggested that the expression of both VEGF and/or TGF-β1 can be useful predictive prognostic factors RCC. In addition, a multivariate analysis demonstrated MVD to be an independent prognostic factor of RCC.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.0919-8172.2003.00608.x
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  • 5
    Electronic Resource
    Electronic Resource
    Long-term survival following radical prostatectomy in Japanese men with clinically localized prostate cancer: A single institutional study (2004)
    Melbourne, Australia : Blackwell Science Pty
    International journal of urology 11 (2004), S. 0 
    Details
    ISSN: 1442-2042
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background:  We evaluated the outcome of radical prostatectomy to provide information about long-term survival following this procedure.Methods:  One hundred and twenty-three otherwise healthy Japanese patients with clinically localized tumors underwent radical prostatectomy. Treatment outcomes were measured in terms of clinical progression-free survival, prostate cancer-specific survival and overall survival. Overall survival was compared with expected survival of age-matched Japanese men.Results:  For these 123 patients, clinical progression-free survival and prostate cancer-specific survival at 10 years were 72.5% and 86.4%, respectively. Results of Cox multivariate analysis showed that only pathological stage (P = 0.047) and tumor grade (P = 0.009) were independent predictors of clinical progression. Only tumor grade was a statistically significant independent predictor (P = 0.048) in terms of prostate cancer death. Both the 10 and 15-year overall survival rates for these 123 patients were 58.6%, whereas the expected survival of age-matched Japanese men was 65.0% at the 10-year follow up, and 43.8% at the 15-year follow up.Conclusions:  The long-term overall survival in this surgically treated group is comparable to the expected survival rate of age-matched Japanese men. These results might be useful in counselling patients with clinically localized prostate cancer.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1442-2042.2004.00911.x
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  • 6
    Electronic Resource
    Electronic Resource
    Influence of 5-hydroxytryptamine and the effect of a new serotonin receptor antagonist (sarpogrelate) on detrusor smooth muscle of streptozotocin-induced diabetes mellitus in the rat (2000)
    Melbourne, Australia : Blackwell Science Pty
    International journal of urology 7 (2000), S. 0 
    Details
    ISSN: 1442-2042
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background : We evaluated the changes in the response of detrusor muscle to 5-hydroxytryptamine (5-HT; serotonin) and its receptor mechanisms in pathologic bladder of diabetes mellitus rats. Methods : Eight-week-old male Wistar rats were given an intraperitoneal injection of streptozotocin (STZ, 60 mg/kg) in order to induce diabetes mellitus (4 weeks’ duration). The bladder strips (10 × 2 mm) were subjected to a tension of 1.0 g in organ baths for the measurements of isotonic contractile responses to 5-HT or relaxation responses to 5-HT antagonists. Results : Bladder strips from STZ-diabetic rats responded to 5-HT with greater contractions than did those of control rats, given vehicle alone. However, bladder strip weights gradually increased in the STZ-diabetic rats as compared with control rats and when the contractile response to 5-HT was expressed as a percentage of the response to 10–1 mol/L KCl there was no statistically significant difference between the groups. In both control and diabetic rats, the 5-HT3 selective antagonist did not markedly inhibit the contractile response to 5-HT. In contrast, the 5-HT2A selective antagonist inhibited the contractile response to 5-HT in a dose-dependent manner. Conclusions : These results suggest that the increased contractile response to 5-HT in diabetic rats’ bladder is related to smooth muscle hypertrophy and/or hyperplasia and indicate that this effect is mediated by activation of 5-HT2A receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1442-2042.2000.00180.x
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  • 7
    Electronic Resource
    Electronic Resource
    Electron Microscopic Study of the Penile Plaques and Adjacent Corpora Cavernosa in Peyronie's Disease (1997)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of urology 4 (1997), S. 0 
    Details
    ISSN: 1442-2042
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background We conducted ultrastructural studies to clarify the fine structure of penile plaques and adjacent corpora cavernosa, and the causative basis for the process, in Peyronie's disease. Methods Penile plaques and adjacent corpora cavernosa were obtained during surgical extirpation from 5 patients with Peyronie's disease. Control tissues from the tunica albuginea and adjacent corpora cavernosa were obtained at penile amputation from 2 patients with penile cancer. Prepared tissues were examined by using electron microscopy. Results Penile plaques were composed of collagen fibrils, amorphous particulate material, and fibroblasts in all patients. In 1 of 5 patients, myofibroblasts were found in the border area between the lesion and underlying structures. Smooth-muscle cells and endothelial cells resembling myofibroblasts were noted in adjacent corpora cavernosa. In this patient, the plaque progressively enlarged, and was removed within 1 year of onset of the induration. Conclusions Fibromatosis in Peyronie's disease involves both fibroblasts and myofibroblasts, which undergo sclerosis in some phase. In addition, smooth-muscle cells and endothelial cells in the adjacent corpora cavernosa may be incorporated in the fibromatosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1442-2042.1997.tb00188.x
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  • 8
    Electronic Resource
    Electronic Resource
    Multivariate analysis of clinicopathologic factors and the efficacy of postoperative IFN-γ adjuvant therapy in 115 patients with renal cell carcinoma (1999)
    Springer
    International journal of clinical oncology 4 (1999), S. 164-169 
    Details
    ISSN: 1437-7772
    Keywords: Key words Renal cell carcinoma ; Multivariate analysis ; Clinical outcome ; Postoperative IFN-γ adjuvant therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background. In patients with renal cell carcinoma, the relationship between long term survival and clinicopathologic factors is not clear. We performed a retrospective analysis to determine the usefulness of clinicopathological factors as prognostic predictors in these patients and to evaluate the usefulness of interferon-gamma (IFN-γ) adjuvant therapy in their long term survival. Methods. We performed the analysis in 115 patients with renal cell carcinoma who underwent nephrectomy at our institution, between January 1980 and December 1997. Results. The median follow-up period was 40 months. The overall survival rates at 1, 5, and 10 years were 92.9%, 77.1%, and 77.1%, respectively. Four of the eight prognostic factors evaluated, including growth type, tumor size, clinical stage, local invasion (capsular invasion and microvascular invasion), histopathological architecture, and histopathological grade, were significant by the log-rank test. Multivariate analysis indicated that both growth type (P = 0.0005) and clinical stage (P = 0.0345) were significant independent prognostic factors. Among the 51 patients with clinical stage more advanced than Robson II, or with local invasion, the 5-year survival rate in those with IFN-γ treatment (n = 35) was 68.5 %, while the rate in those without 1FN-γ treatment (n = 16) was 48% (P = 0.0326). Conclusion. This analysis showed that tumor growth type and clinical stage were important prognostic factors. As no effective therapies have yet been established for advanced renal cell carcinoma, further investigation is warranted to determine the value of IFN-γ as a basic therapy for advanced renal cell carcinoma and for these carcinomas of the rapid-growth type.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s101470050047
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  • 9
    Electronic Resource
    Electronic Resource
    An ultrastructural study of nonfunctioning adrenocortical adenoma (1994)
    Springer
    Medical molecular morphology 27 (1994), S. 27-32 
    Details
    ISSN: 1860-1499
    Keywords: Nonfunctioning adrenocortical adenoma ; Ultrastructural study ; Electron microscopy ; Nonfunctioning adrenocortical black adenoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Nonfunctioning adrenocortical adenomas obtained from 40 and 60-year-old males were examined by electron microscopy. Light microscopically, the tumors were shown to consist of clear cells and compact cells in both cases. However, compact cells predominated in the former case, and clear cells in the latter. Electron microscopy revealed that most of the cells in the former case had abundant organelles, including well-developed, smooth and rough endoplasmic reticulum, Golgi apparatus, and mitochondria with elaborate tubulovesicular cristae. The findings resembled those of adenomas with Cushing's syndrome. The latter case revealed a majority of cells with numerous, large lipid vacuoles, moderate amounts of smooth endoplasmic reticulum, Golgi apparatus, and mitochondria with sparse lamellar cristae resembling features of aldosteronoma. These ultrastructural findings suggest that even nonfunctioning adrenocortical adenomas, like functioning adrenocortical adenomas, have some possibility of producing adrenal hormones.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02348223
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  • 10
    Electronic Resource
    Electronic Resource
    An ultrastructural study of two cases of adrenal ganglioneuroma (1995)
    Springer
    Medical molecular morphology 28 (1995), S. 95-101 
    Details
    ISSN: 1860-1499
    Keywords: Adrenal medulla ; Ganglioneuroma ; Electron microscopy ; Ultrastructural study
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Tissue samples of adrenal ganglioneuromas were obtained from two patients: 35- and 47-year-old males. Light microscopic studies showed that these tumors contained Schwann cells and ganglion cells. Electron microscopic examinations revealed numerous unmyelinated and myelinated axons surrounded by Schwann cells. The ganglion cells in the tumors had abundant organelles, such as well-developed cisternae of the rough endoplasmic reticulum, many profiles of the Golgi apparatus, mitochondria, lysosomes, microtubules and neurofilaments. Electron dense cored granules resembling catecholamine granules were present in the ganglion cell bodies and neural processes. These features resmebled those of normal sympathetic ganglion cells. It is concluded that adrenal ganglioneuroma originates from sympathetic ganglion tissue.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02348026
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