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  • 1
    Electronic Resource
    Electronic Resource
    Quantitative analysis of biopolymers by matrix-assisted laser desorption (1993)
    s.l. : American Chemical Society
    Analytical chemistry 65 (1993), S. 2164-2166 
    Details
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ac00063a041
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  • 2
    Electronic Resource
    Electronic Resource
    Regulation of body dimethylsulfoniopropionate (DMSP) content by the copepod Temora longicornis: a test of four mechanisms (2000)
    Springer
    Marine biology 136 (2000), S. 749-757 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Copepods contain dimethylsulfoniopropionate (DMSP) in their tissues in addition to the DMSP in their gut contents and therefore constitute an additional pool of DMSP in the ocean. In the estuarine copepod Temora longicornis Müller, this dynamic pool of DMSP is reduced when external salinity decreases. In the present study the mechanism(s) used by T. longicornis to adjust its DMSP content were examined. Four possible mechanisms were tested in experiments conducted between July 1997 and May 1999: (1) DMSP cleavage, (2) demethylation, (3) conversion to methionine, and (4) release from the body. Tissue extracts of T. longicornis did not exhibit the ability to cleave or demethylate DMSP. In incubation experiments, when external salinity decreased, T. longicornis individuals reduced their DMSP content without increasing their methionine content. The total amount of DMSP in the incubation vials was conserved regardless of salinity. The copepods retained most of the DMSP in their tissues in 30‰ water, but when salinity was reduced to 20‰, the copepods released 41 to 55% of their body DMSP to the surrounding medium; 89 to 91% of the total DMSP was recovered. This suggests that estuarine copepods represent a reservoir of DMSP, which is released as dissolved DMSP upon salinity decline. Therefore, while osmoregulation by these copepods may have little impact on the chemical properties of DMSP, it will affect the partitioning of DMSP between particulate and dissolved phases in the water column.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002270000309
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  • 3
    Electronic Resource
    Electronic Resource
    Exogenous GABA persistently opens Cl− channels in cultured embryonic rat thalamic neurons (1995)
    Springer
    The journal of membrane biology 145 (1995), S. 279-284 
    Details
    ISSN: 1432-1424
    Keywords: Patch-clamp ; GABA ; GABAA receptor ; Embryonic rat ; Thalamus ; Cl− channel
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract We recorded whole-cell Cl− currents in cultured embryonic rat thalamic neurons by brief applications of GABA or the structural analogue muscimol. In 17 of 141 neurons (12%) the Cl− current persisted for a minute or more after the pipette was removed from the bath. Cl− current never persisted after muscimol exposure even in those cells exhibiting persistent GABA-activated currents (PGC). The half decay times (T50) of PGCs were exponentially and asymptotically related to the duration of GABA exposure and could be interrupted or completely aborted by low-pressure application of saline. PGCs were insensitive to membrane potential, to Tiagabine, a nipecotic acid analogue known to block GABA uptake, and persisted in Ca o 2+ -free medium. Fluctuation analysis revealed that PGCs exhibited inferred Cl− channel properties whose kinetic components and estimated average elementary conductance showed no significant difference from those estimated during GABA exposure. The relative contribution of low frequency components was consistently reduced and that of high frequency components modestly increased during PGC compared to those recorded during GABA exposure. Taken together, the results suggest the existence of a superficial compartment in these embryonic neurons that can momentarily accumulate and release exogenous GABA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00232719
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  • 4
    Electronic Resource
    Electronic Resource
    Mapping the locus for familial hypertrophic cardiomyopathy to chromosome 11 in a family with a case of apical hypertrophic cardiomyopathy of the Japanese type (1996)
    Springer
    Human genetics 〈Berlin〉 97 (1996), S. 457-461 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract To identify the disease locus of familial hypertrophic cardiomyopathy (FHC) in a Chinese family, a genetic linkage study was performed using polymorphisms from various chromosomal regions. This family has eight affected members, including a case with typical features of apical hypertrophic cardiomyopathy of the Japanese type. The results revealed significant evidence of linkage of polymorphisms on chromosome 11p13-q13 and FHC in this family with a maximal lod score of 3.38 atθ = 0.00. Our data suggest that the locus responsible for FHC in this family maps to chromosome 11 and that the molecular basis of FHC in the case of apical hypertrophic cardiomyopathy of the Japanese type might be similar to that of other affected members in the same family. Further studies are needed to elucidate the whole spectrum of the genetic basis of apical hypertrophic cardiomyopathy of the Japanese type.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02267066
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  • 5
    Electronic Resource
    Electronic Resource
    No evidence for linkage of familial hypertrophic cardiomyopathy and chromosome 14q1 locus D14S26 in a chinese family: evidence for genetic heterogeneity (1992)
    Springer
    Human genetics 〈Berlin〉 89 (1992), S. 597-601 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary To understand the molecular basis of familial hypertrophic cardiomyopathy (FHC) in the Chinese population, a family with FHC was investigated. Nineteen family members who were 16 years of age or older were examined by M-mode or two-dimensional echocardiography. Eight members were diagnosed to be affected echocardiographically or clinically. Lymphocytes isolated from 20 family members were successfully transformed into permanent lymphoblastoid cell lines by Epstein-Barr virus. Three genomic DNA probes (CRI-L436, CRI-L329, and pSC14) that were derived from chromosome 14q1 loci and demonstrated to be linked closely to FHC were used to probe this family. Using the techniques of restriction fragment length polymorphism (RFLP) and linkage analysis, the probe CRI-L436, which recognized locus D14S26, was found informative in this family. The lod scores were -2.0 at θ = 0.025 and -1.49 at θ = 0.05. Thus, there was no evidence of linkage between the locus D14S26 and the gene for FHC in the pedigree studied. In addition, polymerase chain reaction (PCR) amplification did not indicate a mutation on exon 13 of the β cardiac myosin heavy chain gene as previously reported. Our data suggest that FHC is a genetically heterogeneous disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00221945
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  • 6
    Electronic Resource
    Electronic Resource
    No evidence for linkage of long QT syndrome and chromosome 11p15.5 markers in a Chinese family: evidence for genetic heterogeneity (1994)
    Springer
    Human genetics 〈Berlin〉 94 (1994), S. 364-366 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Recently the defective gene locus in seven Caucasian families with the Romano-Ward form of long QT syndrome (LQT) has been mapped to chromosome 11p. To understand the molecular basis of LQT in Chinese, a three-generation family was investigated. Fourteen family members were studied and five individuals were diagnosed to be affected, according to electrocardiographic criteria. Two genomic DNA probes (c-Ha-ras-3′-HVR and insulin-5′-HVR) and one tetranucleotide repeat polymorphism (THZ) derived from chromosome 11p15.5 loci and previously demonstrated to be closely linked to LQT were used as probes to analyze this family. A lod score of less than -2 was noted for all three polymorphisms. Our data show that there was no evidence of linkage between these three loci and the gene for LQT in this studied family. We believe that this result provides additional evidence for genetic heterogeneity of LQT.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00201594
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  • 7
    Electronic Resource
    Electronic Resource
    Molecular basis of glucose-6-phosphate dehydrogenase (G6PD) deficiency in three Taiwan aboriginal tribes (1995)
    Springer
    Human genetics 〈Berlin〉 95 (1995), S. 630-632 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract We have investigated glucose-6-phosphate dehydrogenase (G6PD) deficiency in 220 unrelated aboriginal male subjects who belong to three different tribes (Saisiat, Ami, and Yami) in Taiwan. Our results show that the G6PD deficiency rates for Saisiat, Ami, and Yami people are 9.0% (6/67), 6.1% (6/99), and 0% (0/54), respectively. Among these deficiency cases, 4 of 6 (66.7%) Saisiat subjects have the 493 A→G mutation and one carries the 1376 G→T mutation, whereas, in Ami subjects, we found that four of six (66.7%) affected males have the 592 C→T mutation and one carries the 493 A→G mutation. These results contrast with our previous findings for Taiwan Chinese, in whom the 1376 G→T mutation is the major mutant allele and accounts for 52.3% of the deficiency cases. This is the first report of G6PD deficiency characterized at the DNA level in Taiwan aboriginal populations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00209477
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  • 8
    Electronic Resource
    Electronic Resource
    Interaction potentials for alkali ion–rare gas and halogen ion–rare gas systems (1988)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 88 (1988), S. 6290-6302 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The Tang–Toennies model [J. Chem. Phys. 80, 3725 (1984)] has been modified to predict the potentials for ion–atom systems. First order SCF energies are used to describe the repulsive potential. The long range second order induction and dispersion potential terms up to R−10 are either taken from ab initio calculations or estimated and each term is appropriately damped. The potentials for Li+, Na+, K+, F−, and Cl− interacting with He, Ne, and Ar are found to agree well with both theoretical and experimental data within the expected errors. For comparison with the model new ab initio calculations have been performed for Na+–Ar and the results are in excellent agreement with the model predictions (〈10%).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.454467
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  • 9
    Electronic Resource
    Electronic Resource
    Close-coupling scattering cross sections for Ar–O2 collisions at 97.0 meV (1987)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 87 (1987), S. 5687-5693 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: An exact quantum close-coupling calculation of rotationally inelastic scattering cross sections is performed for the best available anisotropic Ar–O2 potential. 110 coupled channels for 10 rotational states are included for the first 99 partial waves. The convergence is demonstrated with up to 156 coupled channels test calculations for selected partial waves. The results agree qualitatively with former IOS calculations of these cross sections and confirm an about 30% to 50% too small anisotropy of the employed potential.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.453543
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  • 10
    Electronic Resource
    Electronic Resource
    Dipole, quadrupole, and octupole terms in the long-range hyperfine frequency shift for hydrogen in the presence of inert gases (1987)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 86 (1987), S. 3539-3548 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The R−6, R−8, and R−10 terms in the long-range expansion for the hyperfine frequency shift are calculated for hydrogen in the presence of He, Ne, Ar, Kr, and Xe. The R−6 terms are based on the dipole oscillator strength sums. For helium, the R−8 and R−10 terms are based on quadrupole and octupole oscillator strength sums. For the heavier inert gases, the results for the R−8 and R−10 terms are obtained from the sum rules and the static polarizabilities. Upper bounds are also determined for the R−8 and R−10 terms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.451957
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