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Osteoblastoma-like osteosarcoma (2000)

Tani, Takayuki ; Okada, K. ; Shoji, Kazuhiro ; [et al.]

Springer

Skeletal radiology 29 (2000), S. 656-659

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ISSN: 1432-2161

Keywords: Keywords Osteoblastoma-like osteosarcoma ; Osteosarcoma ; Aggressive osteoblastoma ; Fibula ; Radiography ; MRI

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract We report an osteoblastoma-like osteosarcoma in the right proximal fibula in a 22-year-old woman. Radiographs showed an irregular osteolytic lesion from the metaphysis to the epiphysis in the proximal fibula with partial destruction of cortical bone. Tissue from a biopsy indicated a typical osteoblastoma. Curettage and bone graft was performed. One year after the surgery, local recurrence occurred, and a wide excision was performed. Histological examination of the en-bloc surgical specimen revealed the tumor had permeated through the host bony trabeculae, although the nuclear atypia was not marked. Immunohistochemical expression of MIB-1 was detected in 9.0% of cells.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/s002560000271

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A comparative study on acute toxicity of methylarsonic acid, dimethylarsinic acid and trimethylarsine oxide in mice (1989)

Kaise, Toshikazu ; Yamauchi, Hiroshi ; Horiguchi, Yoshiya ; [et al.]

New York, NY [u.a.] : Wiley-Blackwell

Applied Organometallic Chemistry 3 (1989), S. 273-277

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ISSN: 0268-2605

Keywords: Methylarsonic acid ; dimethylarsinic acid ; trimethylarsine oxide ; arsenobetaine ; trimethylarsine ; acute toxicity ; LD50 ; Chemistry ; Organic Chemistry

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: The acute toxicity of methylarsonic acid, CH3AsO(OH)2 (MAA), dimethylarsininc acid, (CH3)2AsO(OH) (DMAA), and trimethylarsine oxide, (CH3)3AsO (TMAO), were examined in mice with oral administration.The LD50 values of MAA, DMAA and TMAO were 1.8, 1.2 and 10.6 g kg-1 respectively. The toxicity of MAA and DMAA was very much lower than that for inorganic arsenic compounds. It was shown that TMAO has a similar acute toxicity to arsenobetaine. On the other hand, when the mice were administered 14.4 g kg-1 of TMAO once only orally, a garlic-like odor (trimethylarsine, (CH3)3As) was definitely detectable in the exhalation of the animals by the human olfactory sense within about a few minutes.

Additional Material: 1 Ill.