ISSN:
1432-8798
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary A tissue culture-adapted pantropic strain, two attenuated live vaccine strains and three neurotropic strains of measles virus were compared as to their growth potential, plaque formation, and interferon production in cell cultures, and pathogenicity for suckling hamsters. The properties characteristic of neurotropic measles strains included an enhanced capacity to form syncytia, a reduced, more cell-restricted proliferation cycle, and the development of large fast-growing plaques in Vero cell cultures under agarose overlay. These properties were pronounced with the hamsteradapted HNT and the Vero cell passaged Schwarz vaccine strains, both pathogenic when inoculated intracerebrally into suckling hamsters. Two measles viruses isolated from human brain with subacute sclerosing panencephalitis were not neurotropic for hamsters. Only one of the latter strains retained some of the properties characteristic for neutrotropism. Interferon induction in BS-C-1 cells was enhanced with both the attenuated and the neurotropic virus strains. The most pronounced marker which distinguished the pantropic and neurotropic strains from the vaccine strains was the inability of the former to grow in chick embryo fibroblast cultures.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01249860
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