ISSN:
0001-1541
Keywords:
Chemistry
;
Chemical Engineering
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
,
Process Engineering, Biotechnology, Nutrition Technology
Notes:
The final properties and end use of many organic solids often depends on their crystal-size distribution (CSD), e.g., bioavailability for pharmaceutical solids. The objective of this study was to develop an alternate technology for crystallizing and manipulating size distribution of organic solids by crystallization from supercritical fluids. Such a technology might be superior to conventional-size manipulation techniques, such as milling and recrystallization from organic solvents, which might contaminate the products and affect their physical-chemical stability. Supercritical carbon dioxide was used as solvent to dissolve and then crystallize benzoic acid. A batch crystallizer was constructed and operated in the supercritical region. Seeded and unseeded crystallization experiments were performed. Different depressurization vs. time profiles for the supercritical fluid were used to produce crystals of various sizes.
Additional Material:
8 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/aic.690351006
Permalink
