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  • 1
    Digitale Medien
    Digitale Medien
    THE INFLUENCE OF HEART RATE ON DIGOXIN-INDUCED INHIBITION OF MYOCARDIAL NA+-K+-ATPASE ACTIVITY IN THE DOG (1981)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 8 (1981), S. 0 
    Details
    ISSN: 1440-1681
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: 1. Groups of sedated dogs were studied at spontaneous heart rates (HR), 55–100/min, or at paced HR 200/min, with or without intravenous digoxin administration. After 60 min, active rubidium uptake (86Rb+) of ventricular samples was determined in vitro.2. Untreated fast and slow HR groups had similar uptakes. Following digoxin, 0.08 mg/kg, uptake was less at fast than slow HR (63.8, s.e.m. = 4.5 v. 87.5, s.e.m. = 5.0 pmol/mg LV/15 min, P〈 0.01). After 0.125 mg/kg, values were again lower in the fast HR group in which five of seven developed ventricular tachycardia.3. Heart rate does not alter in vitro activity of myocardial Na+-K+-ATPase but does influence inhibition of the enzyme resulting from digoxin administration.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1440-1681.1981.tb00161.x
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  • 2
    Digitale Medien
    Digitale Medien
    CARDIAC β-ADRENORECEPTORS IN THE THYROXINE-TREATED DOG (1981)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 8 (1981), S. 0 
    Details
    ISSN: 1440-1681
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: 1. Myocardial β-adrenoreceptors, assessed in membrane preparations of left ventricle by 3 H-dihydroalprenolol binding, were compared in dogs following thyroxine administration (n= 6), aortocaval fistula (n= 12), and in normal dogs (n= 7).2. Left ventricular hypertrophy occurred in response to both aortocaval fistula and thyroxine treatment. Yield of myocardial membrane between the different groups was not significantly different.3. Binding site concentration (pmol/mg membrane protein) in dogs with aortocaval fistulae was similar to that in normal dogs and was not significantly influenced by the presence or absence of cardiac failure, degree of hypertrophy or duration of fistula.4. Thyroxine-treated dogs had an increased concentration of binding sites (c. 1.8-fold) compared with both fistula and normal groups, while binding affinities were similar in all groups.5. The data suggest that β-adrenoreceptor concentrations in myocardium increase as a direct result of thyroid hormone action rather than as a result of secondary haemodynamic changes or ventricular hypertrophy.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1440-1681.1981.tb00150.x
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  • 3
    Digitale Medien
    Digitale Medien
    WHOLE BLOOD PLATELET AGGREGATION IS NOT AFFECTED BY CIGARETTE SMOKING BUT IS SEX-RELATED (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 14 (1987), S. 0 
    Details
    ISSN: 1440-1681
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: 1. In normal subjects, 18–49 years old, the effects of the smoking habit (〉10 cigarettes/day) and the act of smoking two cigarettes over 10 min were studied on whole blood platelet aggregation (in vitro impedance method).2. Acute smoking (n= 10) did not affect platelet aggregation to ADP, collagen or to platelet activating factor (PAF) nor thromboxane B2 production during aggregation. There was no difference between smokers (n= 13) and non-smokers (n= 10). However, aggregation to all aggregants was greater in females (n= 11) than males (n= 12) (ADP and collagen, P 〈0.001; PAF, P 〈0.01; ANOVA).3. Although others have obtained diverse results studying platelet-rich plasma, the absence of an effect of cigarette smoking on whole blood platelet aggregation is consistent with many of those observations. Greater in vitro aggregability in females than males is consistent with the few studies of platelet-rich plasma. It seems unlikely that the role of cigarette smoking as a risk factor for ischaemic heart disease is related to a direct effect on platelet aggregability.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1440-1681.1987.tb01888.x
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  • 4
    Digitale Medien
    Digitale Medien
    EFFECT OF CIGARETTE SMOKING ON THE FREQUENCY OF VENTRICULAR PREMATURE COMPLEXES IN NORMAL SUBJECTS (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 16 (1989), S. 0 
    Details
    ISSN: 1440-1681
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: 1. Ambulatory ECG monitoring was undertaken in healthy cigarette smokers (33) and non-smokers (20) of similar age (21–66 years).2. The frequency of ventricular premature complexes (VPC) was less in habitual smokers (P 〈 0,05; Mann-Whitney rank test) and an average of more than 1 VPC per hour occurred in a higher proportion of non-smokers than smokers: eight of 20 (40%) vs two of 33 (6%) (P 〈 0.01; Chi-square test).
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1440-1681.1989.tb01616.x
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  • 5
    Digitale Medien
    Digitale Medien
    THE MEASUREMENT OF PLASMA THROMBOXANE B2 AND THE EFFECT OF SMOKING (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 11 (1984), S. 0 
    Details
    ISSN: 1440-1681
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: 1. Plasma thromboxane B2 (TxB2) was measured by radioimmunoassay using an iodinated ligand following extraction and further purification by thin layer chromatography. Venous blood was sampled into a syringe containing the cyclooxygenase inhibitor meclofenamate.2. Normal levels, 15 pg/ml (s.d. = 8, n= 21), were lower than usually reported and measured values increased several fold over 20 min sampling from an indwelling needle.3. With appropriate sampling there was a statistically insignificant increase in plasma TxB2 after subjects smoked two cigarettes (n= 11). An average decrease occurred in a control group (n= 10) and the difference between groups was of borderline significance (P〈0.05). Smoking did not change TxB2 production associated with platelet aggregation induced in vitro by collagen, whereas plasma adrenaline increased significantly.4. The results emphasize the importance of the technique of sampling and assay in the measurement of plasma TxB2.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1440-1681.1984.tb00874.x
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  • 6
    Digitale Medien
    Digitale Medien
    β-ADRENOCEPTORS IN THE HYPERTROPHIED RIGHT VENTRICLE OF THE DOG WITH PULMONARY STENOSIS (1983)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 10 (1983), S. 0 
    Details
    ISSN: 1440-1681
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: 1.Right ventricular hypertrophy was produced in dogs by banding of the pulmonary artery for 28 days (n= 7) and results were compared with those in sham-operated dogs (n= 5).2. Myocardial noradrenaline and adrenaline levels were depressed in both the hypertrophied right ventricle and the non-hypertrophied left ventricle and plasma levels were increased compared to the control dogs.3. Myocardial β-adrenoceptors were assessed in membrane preparations of both ventricles by 3H-dihydroalprenolol binding. No change in binding site concentration (pmol/mg membrane protein) or in binding affinity was found in either the hypertrophied right ventricle or in the left ventricle.4. Divergent results of studies on β-adrenoceptors in ventricular hypertrophy are difficult to reconcile.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1440-1681.1983.tb00167.x
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