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  • 1
    Electronic Resource
    Electronic Resource
    Problems in the use of polycarbonate diffusion chambers for syngeneic pancreatic islet transplantation in rats (1980)
    Springer
    Diabetologia 18 (1980), S. 313-317 
    Details
    ISSN: 1432-0428
    Keywords: Transplantation ; islets of Langerhans ; streptozotocin diabetes ; diffusion chambers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Islets of Langerhans have been enclosed in polycarbonate diffusion chambers and transplanted intraperitoneally to syngeneic streptozotocin diabetic rats. Direct implantation of 1100–1400 islets in these chambers failed to reverse diabetes during a period of 12 weeks, and viable islet tissue was not recoverable at the end of this period. Islets placed in chambers which had been implanted 3–12 weeks previously similarly failed to lower blood glucose of diabetic recipients, as a result of lack of survival of the islets. Insulin infusion into chambers previously implanted in vivo, I125 insulin diffusion studies in chambers recovered 6–8 weeks after implantation, and scanning electron microscopy of the recovered membranes all indicated that the pores were not totally occluded. The failure of islet transplantation via chambers in this simple syngeneic model has discouraging implications for their use as a means of avoiding allograft rejection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00251012
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Cavernous haemangioma of breast in a man with contralateral gynaecomastia and a family history of breast carcinoma (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 13 (1988), S. 0 
    Details
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A 73-year-old man with a cavernous haemangioma of the right breast is presented. The patient had had gynaecomastia of the left breast 8 years earlier. Prior to that he had been on cimetidine for 2 years. The patient's mother and sister had breast carcinomas, while two other sisters and a brother had carcinomas of kidney, uterus and lung respectively.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2559.1988.tb02027.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The value of radioimmunoguided surgery in first and second look laparotomy for colorectal cancer (1991)
    Springer
    Diseases of the colon & rectum 34 (1991), S. 217-222 
    Details
    ISSN: 1530-0358
    Keywords: Radioimmunoguided surgery ; Colorectal cancer
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Radioimmunoguided surgery (RIGS) using an anti-CEA (A5B7) monoclonal antibody has been assessed in 52 patients (43 primary excisions and nine second look procedures) undergoing surgery for colorectal carcinoma. The antibody localized in 97.8 percent of primary tumours and in 88.8 percent of the principal tumor in second look procedures. Additional information concerning the extent of primary tumor was obtained in 11 of 43 patients (25.5 percent) undergoing excision of primary carcinoma and five of nine patients (55 percent) in the second look series. Incorrect information was obtained about the extent of the primary tumour in six patients (11.3 percent), whereas no incorrect information was obtained during second look procedures. RIGS correctly predicted the subsequent Dukes' staging in 77 percent of first look cases (sensitivity 65 percent, specificity 90 percent), although accurate identification of individual nodes was impossible. The technique influenced the surgical procedure performed in 2 of 43 cases (4.6 percent) in primary surgery and in three of nine patients undergoing second look laparotomy (33 percent). RIGS in primary colorectal carcinoma may provide additional information concerning extent of locally advanced tumors in particular and the principle that the subsequent surgery may be influenced has been established. The technique appears to have a greater role in second look procedures where it may help determine the extent of recurrent tumour. Larger follow-up series are required to define how the additional information provided by this technique may best be exploited.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02090160
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    Paper (German National Licenses)
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