ISSN:
1432-1076
Keywords:
Fibrinogen half-life
;
Cyanotic congenital heart disease
;
Polycythemia
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Fibrinogen half-life was determined in 3 healthy individuals and in 17 children with cyanotic congenital heart disease. Fibrinogen half-life was normal in the healthy individuals and shortened in 9 of the 17 patients. The simultaneously performed coagulation tests were often pathological but did not lead to a clear diagnosis of the haemostatic defect and did not correlate with the fibrinogen half-life. Significant correlations were found between fibrinogen half-life and red cell count (P〈0.001), packed cell volume (P〈0.001), mean corpuscular volume of the red cell (P〈0.001), platelet count (P〈0.01), aortic oxygen saturation (P〈0.001), base excess (P〈0.01), and maximal amplitude of the thrombelastography (P〈0.001). The results indicate a definite relationship between the hypoxaemia and the frequently observed disturbance of haemostasis in cyanotic heart disease. The chronic hypoxaemia causes a partly compensated intravascular coagulation with increased fibrinogen metabolism.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00442078
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