ISSN:
1600-0714
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Differences in expression of intercellular adhesion molecule-1 (ICAM-1) and ICAM-1 mRNA levels were studied in cultured skin and oral keratinocytes before and after stimulation with different pro-inflammatory cytokines. Basal expression of ICAM-1 was undetectable on skin keratinocytes but oral keratinocytes expressed ICAM-1 at high levels. Interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α) increased ICAM-1 expression on both cell types, although TNF-α had a greater effect on oral than skin keratinocytes (P 〈 0.05) and IFN-γ was more effective than TNF-α on both cell types (P 〈 0.01). In combination, TNF-α and IFN-γ synergistically increased ICAM-1 expression on skin keratinocytes only, although ICAM-1 mRNA was synergistically increased in both cell types. IL-lα and IL-1β induced a small increase in ICAM-1 expression on oral keratinocytes but had no effect on skin keratinocytes.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1600-0714.1996.tb00204.x
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