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  • 1
    Electronic Resource
    Electronic Resource
    Segregated mathematical model for the fed-batch cultivation of a high-producing strain of Penicillium chrysogenum
    Amsterdam : Elsevier
    Journal of Biotechnology 34 (1994), S. 119-131 
    Details
    ISSN: 0168-1656
    Keywords: Fed batch ; Pellet ; Penicillium chrysogenum ; Segregated model
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0168-1656(94)90082-5
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Two mathematical models for the development of a single microbial pellet (1995)
    Springer
    Bioprocess and biosystems engineering 12 (1995), S. 305-313 
    Details
    ISSN: 1432-0797
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract A mathematical model for pellet development of filamentous microorganisms is presented, which simulates in detail location and growth of single hyphal elements. The basic model for growth, septation and branching of discrete hyphae is adopted from Yang et al. [2, 23]. Exact solutions to the intracellular mass-balance equations of a growth-limiting key component is given for two types of either branched or unbranched cellular compartments. Furthermore, the growth model was extended in regard to the external mass-balance equations of limiting substrates (oxygen, glucose) under the assumption that the substrates can enter the denser regions of the pellet only diffusively. Penetration of the substrates into the more porous outer regions of the pellet occurs more easily due to microeddies in the surrounding fluid. Chipping of hyphae from the pellet surface by shear forces was included in the model as well. The application of shear forces leads to a marked smoothing of the simulated pellet surface. The development of pellets from spore germination up to late stages with cell-lysis due to shortage of substrates in the pellet centre can be described. The effects of various model parameters are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00369507
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Two mathematical models for the development of a single microbial pellet (1995)
    Springer
    Bioprocess engineering 12 (1995), S. 305-313 
    Details
    ISSN: 0178-515X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract  A mathematical model for pellet development of filamentous microorganisms is presented, which simulates in detail location and growth of single hyphal elements. The basic model for growth, septation and branching of discrete hyphae is adopted from Yang et al. [2, 23]. Exact solutions to the intracellular mass-balance equations of a growth-limiting key component is given for two types of either branched or unbranched cellular compartments. Furthermore, the growth model was extended in regard to the external mass-balance equations of limiting substrates (oxygen, glucose) under the assumption that the substrates can enter the denser regions of the pellet only diffusively. Penetration of the substrates into the more porous outer regions of the pellet occurs more easily due to microeddies in the surrounding fluid. Chipping of hyphae from the pellet surface by shear forces was included in the model as well. The application of shear forces leads to a marked smoothing of the simulated pellet surface. The development of pellets from spore germination up to late stages with cell-lysis due to shortage of substrates in the pellet centre can be described. The effects of various model parameters are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00369507
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Modellbank Biotechnologie - Ein Softwarepaket zur Modellauswahl, Optimierung und Simulation biotechnologischer Prozesseveröffentlicht im Tagungsband des Kolloquiums, AdW der DDR, Zentrum für wissenschaftlichen Gerätebau, Mytron, 1989. (1989)
    Berlin : Wiley-Blackwell
    Acta Biotechnologica 9 (1989), S. 529-533 
    Details
    ISSN: 0138-4988
    Keywords: Life Sciences ; Life Sciences (general)
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: The MODELBASE BIOTECHNOLOGY has been developed for gathering and processing data obtained from biochemical experiments. It covers the analysis of growth kinetics and production kinetics as well and may be used for calibration curve determination too. The implementation of models defined by the user is supported. Both, differential equations and their integrated forms are accepted. In addition to parameter estimation a statistical analysis can be carried on request. Two and three dimensional graphical representation facilitates the interpretation of results.Fields of application are biochemistry, biotechnology, microbiology, engineering, pharmacy, equipment design, education.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/abio.370090607
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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