ISSN:
1432-2277
Keywords:
Cyclosporin A, renal transplantation, children
;
Renal transplantation, children, CyA
;
Pediatric, CyA, renal transplantation
;
Pharmacokinetics, children, CyA
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract To study the long-term effect of cyclosporin A (CyA), 94 6-h and 29 12-h pharmacokinetic profiles were evaluated in 32 children at least 1 year after renal transplantation. Children weighing less than 25 kg needed significantly higher doses of CyA than those weighing more than 25 kg(9.8 vs 5.3 mg/kg per day; P〈0.001) to achieve similar trough levels (TL). The average dose of CyA required to achieve the target TL declined gradually with time after transplantation. The average area under the curve over 6 h (AUC/6) correlated strongly with the AUC/12 (r=0.967; P〈0.001). The AUC/6 of patients with biopsy-proven CyA toxicity was significantly higher than for those without toxicity (Mann-Whitney U-test P〈0.05) despite similar TL. We conclude that AUC monitoring for 6 h provides valuable information not only on TL but also on the absorption and elimination characteristics of CyA as well as on the potential for CyA toxicity.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00335553
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