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Single dose primaquine has no effect on paracetamol clearance (1987)

Back, D. J. ; Tjia, J. F.

Springer

European journal of clinical pharmacology 32 (1987), S. 203-205

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ISSN: 1432-1041

Keywords: paracetamol ; primaquine ; drug interaction ; metabolite formation ; pharmacokinetics

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary The kinetics of paracetamol and the formation of metabolites were evaluated in 6 healthy volunteers before and during concomitant administration of a single dose (45 mg) of primaquine. There was no effect of the antimalarial drug on either conjugation (to paracetamol glucuronide and paracetamol sulphate) or oxidation (as judged by the presence of paracetamol cysteine and paracetamol mercapturate) pathways. Although primaquine inhibits certain oxidative metabolism (e.g. of antipyrine) it has no effect, in therapeutic doses, on paracetamol metabolism.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00542197

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The in-vitro mucosal conjugation of ethinyloestradiol and the bioavailability of oral contraceptive steroids in patients with treated and untreated coeliac disease (1992)

GRIMMER, S. F. M. ; BACK, D. J. ; ORME, M. L'E. ; [et al.]

Oxford, UK : Blackwell Publishing Ltd

Alimentary pharmacology & therapeutics 6 (1992), S. 0

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ISSN: 1365-2036

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: The ethinyloestradiol (EO2) component of oral contraceptive steroids is extensively conjugated with sulphate by the gut wall. The ability of gastrointestinal mucosa to conjugate EO2 has been examined in vitro in samples of mucosa taken from normal women as well as from women with coeliac disease. The percentage conjugation per mg dry weight for normal tissue (n= 11) was 17.1 ± 6.4 (mean ± s.d.) while in untreated coeliac tissue (n= 6) the figure was 6.3 ± 3.6% (P 〈 0.01). In tissue from patients with treated coeliac disease (n= 5) the figure was 12.1 ± 3.2%.Thus the ability of intestinal mucosa to conjugate ethinyloestradiol was significantly reduced in patients with coeliac disease, and restored towards normal following treatment. However, in patients with coeliac disease the pharmacokinetics of ethinyloestradiol were not significantly different from normal controls.