ISSN:
1434-4726
Keywords:
Key words Respiratory cilia
;
Mucociliary transport
;
Transmission electron microscopy
;
Dynein arms
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Clinical significance of short outer dynein arms was examined in a long-term follow-up study of 76 patients with various respiratory symptoms. Clinical evaluations, nasal mucociliary transport rate (NMTR) measurement and transmission electron microscopy were performed. Follow-up examinations took place 5–11 years later. In the initial examination four patients and on follow-up seven patients were found to have short outer dynein arms in their nasal mucosal biopsies. Short dynein arms were associated with a slow NMTR, poorly coordinated ciliary beat direction, and clinical symptoms of perennial rhinitis and recurrent sinusitis. Short dynein arms were found to be a significant histologic finding and probably represent a variant of primary ciliary dyskinesia. In some cases short outer dynein arms may be a reversible finding with improving clinical symptoms. It is obvious that at least part of dynein defects are acquired.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s004050050106
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