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Binding of (+)PHNO and other D2-dopamine agonists to D1-dopamine receptors labelled by [3H]SCH 23390 (1987)

Pettibone, D. J. ; Totaro, J. A. ; Clineschmidt, B. V.

Springer

Journal of neural transmission 69 (1987), S. 147-151

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ISSN: 1435-1463

Keywords: (+)PHNO ; L-647 ; 339 ; [3H]SCH 23390 binding ; dopamine receptor subtypes

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary The affinity of (+)PHNO for the D1-dopamine receptor subtype in striatal tissue was determined in a radioligand binding assay using the D1-selective compound, [3H]SCH 23390. The IC50 for (+)PHNO was 22ΜM, a value considerably higher than obtained for reference agents (lisuride, apomorphine, pergolide, [−]EOE and bromocriptine). The low potency of (+)PHNO at the D1-receptor subtype contrasts with the compound's high potency at the D2-receptor subtype, as reported previously. (+)PHNO can, therefore, be classified as a very selective D2-receptor agonist.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01244105

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