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  • 1
    Electronic Resource
    Electronic Resource
    Three-dimensional structure of the gustatory cell in the mouse fungiform taste buds: a computer-assisted reconstruction from serial ultrathin sections (1995)
    Springer
    Anatomy and embryology 191 (1995), S. 83-88 
    Details
    ISSN: 1432-0568
    Keywords: Taste bud ; Gustatory cells ; Fungiform papillae ; Three-dimensional reconstruction ; Mouse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Taste buds in fungiform papillae of the mouse were examined with transmission electron microscopy and computer-assisted, three-dimensional reconstructions from serial ultrathin sections. In accord with observation by Murray (1971), four distinct cell types, type I, II, III and basal cells, were identified. Of these, only the type III cell made synaptic contacts with nerve terminals and contained both small, clear vesicles and dense-cored granules. The former vesicles were synaptic-type and accumulated in the cytoplasm just below the synaptic in membrane thickenings. This finding clearly indicates a sensory function for the type III cell. One to three type III cells were identified within a taste bud. The type III cell had at most eight synapses with nerve terminals. One nerve fiber making two synapses with the type III cell was occasionally observed in its terminal region.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00186781
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  • 2
    Electronic Resource
    Electronic Resource
    Establishment of ameloblastoma cell line, AM-1 (1998)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 27 (1998), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Ameloblastomas are slowly growing, locally invasive neoplasms with a potentially destructive behaviour. The molecular mechanisms that regulate the cell growth and invasion of ameloblastoma cells are unknown. Because ameloblastoma cells placed in culture have a very limited lifespan, the establishment of immortalized clones of ameloblastoma cells would aid its study. We produced an immortalized ameloblastoma cell line (AM-1) using human papillomavirus type-16. This cell line maintains epithelial cell morphology and expresses cytokeratins K8, K14, K18, K19. Furthermore, bcl-2 protein, which prevents apoptosis, is expressed. We investigated the behaviour of these cells on a collagen matrix in vitro. These cells grew in a monolayer over foci of collagen degradation and could invade the collagen gel at such sites. Since the behavior of cell line AM-1 mimics the behavior of ameloblastoma in vivo, it may be a valuable model for the study of these neoplasms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0714.1998.tb01943.x
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  • 3
    Electronic Resource
    Electronic Resource
    Overexpression of bcl-2 protein inhibits terminal differentiation of oral keratinocytes in vitro (1998)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 27 (1998), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Harada H, Mitsuyasu T, Seta Y. Maruoka Y, Toyoshima K, Yasumoto S: Overexpression of bcl-2 protein inhibits terminal differentiation of oral keratinocytes in vitro. J Oral Pathol Med 1998; 27: 11–7. © Munksgaard, 1998.The bcl-2 proto-oncogene is a known inhibitor of apoptosis; in normal human stratified squamous epithelium, its expression is restricted to the basal cell layer. To investigate the functional role of bcl-2 protein in the process of differentiation of oral keratinocytes, bcl-2 expression vector was transfected into SCC-25 cells, which normally undergo squamous cell differentiation in vitro while expressing specific differentiation markers, e.g., keratin 10/11 and involucrin. In bcl-2 transfected SCC-25 cells, the expression of these differentiation markers was markedly suppressed. The bcl-2 proto-oncogene may play a critical role in opposing the commitment to terminal differentiation and apoptosis of oral keratinocytes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0714.1998.tb02084.x
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  • 4
    Electronic Resource
    Electronic Resource
    Immunohistochemical demonstration of bcl-2 protein in ameloblastoma (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 26 (1997), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The bcl-2 gene is known through its product, bcl-2 protein, which prevents apoptosis. and also by its expression in development, especially in sites characterized by epithelial-mesenchymal interactions. In the developing tooth germ, bcl-2-protein is expressed in the epithelial component. In this study, we examined the expression of bcl-2 protein immunohistochemically in 25 ameloblastomas using a monoclonal antibody against anti-human bcl-2 oncoprotein. In all 25 cases, bcl-2 protein was found mainly in the outer layer of tumor cells, whereas the inner cells (stellate reticulum-like cells and squamoid cells) were negative. The bcl-2 protein is therefore thought to play a role in maintaining the stem-cell population in the peripheral layers of the tumor nests from which proliferating cells can be recruited.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0714.1997.tb00228.x
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  • 5
    Electronic Resource
    Electronic Resource
    Ultrastructure of Merkel corpuscles in the tongue of the finch, Lonchura striata (1991)
    Springer
    Cell & tissue research 264 (1991), S. 427-436 
    Details
    ISSN: 1432-0878
    Keywords: Merkel cells (corpuscles) ; Tongue ; Exocytosis ; Nerve endings ; Paraneurons ; Lonchura striata (Aves, Passeriformes)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Merkel corpuscles in the lingual mucosa of the finch, Lonchura striata, were examined by means of the argyrophilic reaction and electron microscopy. These corpuscles are composed of 12 to 20 flattened Merkel cells and enclosed nerve terminals. The present study demonstrated for the first time argyrophilia in avian subepithelial Merkel cells with the use of Grimelius silver stain. Electron-microscopically, the Merkel cell was characterized by the presence of numerous densecore granules, approximately 80 to 140 nm in diameter, as well as specialized contacts with nerve terminals. The granules showed a tendency to accumulate in the cytoplasm in close association with both nerve terminals and basal lamina. This study also provided unequivocal evidence for exocytotic discharge of Merkel-cell granules at the plasma membrane facing not only the nerve terminals but also the basal lamina. The exocytotic figures toward the nerve terminals can be regarded as synaptic discharge of Merkel-cell granules, but the possibility also exists that the Merkel-cell granules may exert a trophic effect on the nerve terminals. The exocytotic release of Merkel-cell granules toward the basal lamina with no relation to nerve terminals may suggest an endocrine (paracrine) function for the Merkel cell. The avian subepithelial Merkel cells qualify as paraneurons, but their exact nature and function remain enigmatic as is the case of intraepithelial Merkel cells in other vertebrates.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00319033
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  • 6
    Electronic Resource
    Electronic Resource
    The occurrence of ciliated and mucous cells in the peripapillary trench of the rat tongue (1979)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 195 (1979), S. 301-309 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Ciliated cells surrounded by mucous cells were found near the base of the peripapillary trench of the rat circumvallate papilla. The ciliated cells occurred singly or in small groups. Each cilium showed the nine plus two filament pattern characteristic of motile cilia.We consider that these cells function in wetting the taste pores, circulating saliva containingtastants and removal of debris from the papillary trench.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1091950205
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  • 7
    Electronic Resource
    Electronic Resource
    Dividing type II cell in rabbit taste bud (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 214 (1986), S. 161-164 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Examination of rabbit foliate papillae by electron microscopy revealed for the first time the existence of a dividing cell within a taste bud. The ultrastructure of this cell was in keeping with that of type II cells of the sort located in the center of taste buds. Whether this cell is capable of differentiating into other cell types is still unclear.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1092140209
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  • 8
    Electronic Resource
    Electronic Resource
    Ultrastructure of the sublingual gland in the African multimammate rodent (1991)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 229 (1991), S. 482-488 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The sublingual gland of Praomys natalensis, an African rodent that is phenotypically and cytogenetically intermediate to mice and rats, is a mixed gland, consisting of mucous acini that are capped by serous demilunes, of intercalated ducts, and of some short striated ducts that quickly become excretory ducts. The mucous cells are typical in appearance, with lucent granules that contain an assortment of scattered vermiform or particulate densities. The serous cells display an array of secretory granules with a highly unusual substructure. Rather than a pattern based on the manner in which light and dark regions are disposed in their matrix, these granules contain packets - some furled, some flat - of membranes that exhibit a pronounced axial periodicity of ∼5 nm. Intercalated ducts are simple in structure, with no obvious morphological specializations. Striated ducts resemble those in the salivary glands of less exotic rodents, but they and the excretory ducts often have clusters of cytoplasmic crystalloids consisting of linear densities that intersect at right angles and that have a periodicity in both directions of ∼ 12 nm.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1092290407
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  • 9
    Electronic Resource
    Electronic Resource
    Comparative study of ultrastructures of the lateral-line organs and the palatal taste organs in the African clawed toad, Xenopus laevis (1982)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 204 (1982), S. 371-381 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The fine structure of the lateral-line organ and the palatal taste organ in the African clawed toad, Xenopus laevis, was examined by means of electron microscopy.The lateral-line organ consisted of hair and accessory cells. The apical surface of a hair cell was studded with one kinocilium and 20 to 40 stereocilia. Synaptic bodies and subsynaptic cisternae were found in the cytoplasm of a hair cell adjacent to the synaptic contacts with the afferent and the efferent nerve endings, respectively. Crystalline bodies were observed in both the nucleoplasm and the cytoplasm of almost all hair cells.The palatal taste organ consisted of three types of cells: the taste, sustentacular, and the Merkel cells. The taste cells contained numerous dense-cored vesicles which accumulated in close association with both the afferent synapses and the basal plasma membrane. The possibility was raised from the ultrastructural results that these vesicles had dual functions as both neurotransmitter and hormone. The existence of Merkel cells in the palatal taste organ suggested that this organ might function not only as a chemoreceptor but also as a mechanoreceptor.In spite of possible chemosensory function of the lateral-line organ in Xenopus, its ultrastructure was significantly different from that of the typical gustatory organ, the palatal taste organ, in this animal.
    Additional Material: 17 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1092040411
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  • 10
    Electronic Resource
    Electronic Resource
    Ultrastructure of the submandibular gland in the African multimammate rodent, Praomys natalensis (1991)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 229 (1991), S. 209-218 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Praomys natalensis, an African rodent that is phenotypically and cytogenetically intermediate to rats and mice, possesses a submandibular gland that is histologically similar to that in both of these near relatives, but is ultra-structurally unique. Acinar cells, which are seromucous in nature, contain secretory granules that often contain a perfect “bull's eye” inclusion (or some variant of this configuration) suspended in a dense matrix. The Golgi apparatus in these cells has an unusual structure, with the Golgi saccules often being doubled over, so that the outermost saccule also is the innermost. This peculiar architecture apparently arises fairly late in the secretory process, i.e., a Golgi apparatus of conventional structure gives rise to a nascent granule (condensing vacuole), then its saccules secondarily fold over. Intercalated ducts are preceded by a ring of specialized cells that have a number of serous-type granules, the duct cells themselves being devoid of such granules. Granular convoluted tubules (GCT) contain large dense granules that appear to be spontaneously involved in chain exocytosis. These GCT granules probably are the repositories of nerve growth factor, which is particularly abundant in Praomys. Striated ducts for the most part are typical in appearance, but they and, to a lesser extent, GCTs contain prominent, membrane-bound crystalloids with a periodicity of about 15 nm.
    Additional Material: 18 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1092290208
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