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  • 1
    Electronic Resource
    Electronic Resource
    Effect on heart rate over 24 hours of pindolol administered for 14 days (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 535-538 
    Details
    ISSN: 1432-1041
    Keywords: pindolol ; healthy volunteers ; heart rate ; intrinsic sympathomimetic activity ; diurnal heart rate ; nocturnal heart rate ; rebound effect
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect on heart rate of pindolol 5, 15 and 30 mg/day, a beta-adrenoreceptor blocker possessing intrinsic sympathomimetic activity, administered to 8 healthy volunteers for 14 days was studied. Heart rate was continuously recorded over 24 h during placebo treatment before each sequence, every 2 days during treatment, and then on the 15th, 17th and 18th days. Pindolol in the three doses used had no significant effect on mean heart rate over 24 h. It tended to lower mean diurnal heart rate non-significantly between noon and 6 p.m. Pindolol raised nocturnal heart rate between midnight and 6 a.m. to a comparable extent at all the doses used. Sympathetic tone is at its lowest during that period, which makes it possible to detect the intrinsic sympathomimetic activity of pindolol. After cessation of treatment, a rebound effect was observed, cardioacceleration being most marked after 30 mg/day.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00556888
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Comparison of the central and peripheral effects of cetirizine and terfenadine (1988)
    Springer
    European journal of clinical pharmacology 35 (1988), S. 255-259 
    Details
    ISSN: 1432-1041
    Keywords: cetirizine ; terfenadine ; CNS-/peripheral effects ; allergic disorder ; H1 antagonist
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The peripheral and central effects of 10 mg cetirizine 2 HCl and 60 mg terfenadine have been compared with placebo in 9 healthy male volunteers. The peripheral effect, in terms of cutaneous reactivity to 1 µg histamine i.d., was measured by planimetry of the wheal and erythemas. Central effects were assessed with a self-evaluation visual scale and from the results of electroencephalographic spectrum analysis. Peripheral inhibition of histamine reactivity was more intense and quicker for cetirizine than for terfenadine. On the self-evaluation scale, no significant difference between terfenadine, cetirizine and placebo was noted. The quantified EEG did not show any variation in spectral parameters at any time after cetirizine. By contrast, at 6 h terfenadine had increased slow waves and had inhibited the alpha band. Thus, 10 mg cetirizine 2 HCl had less effect on the central nervous system than terfenadine 60 mg, whilst its peripheral action appeared more quickly and was more intense.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558262
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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